Andronikashvili E L, Esipova N G, Kharatishvili M G
Biofizika. 1988 Sep-Oct;33(5):767-71.
Effect of low concentrations of metal bivalent ions on DNA-distamycin complexes was studied. It has been found that when adding small quantity of Zn2- ions the DNA-distamycin complex changes its cooperative properties. A small amount of heavy metal ions incorporated in DNA changes the DNA property to form complexes capable of stimulating the formation of structures of high organization. Thus under the effect of metal small additions both the structure of cellular processes and their regulation are irreversibly simplified, the phase of rest characterized by the maximal number of organization levels of the nuclear apparatus not being reached.
研究了低浓度二价金属离子对DNA-双间霉素复合物的影响。已发现，当添加少量Zn2+离子时，DNA-双间霉素复合物会改变其协同性质。掺入DNA中的少量重金属离子改变了DNA形成能够刺激高组织结构形成的复合物的性质。因此，在少量金属的作用下，细胞过程的结构及其调节都被不可逆地简化了，静止期也未达到以核装置组织水平数量最多为特征的阶段。
