Department of Pathology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, United States.
Semin Diagn Pathol. 2020 Sep;37(5):228-233. doi: 10.1053/j.semdp.2020.03.002. Epub 2020 Mar 17.
It is recommended by current clinical guidelines that pathologists identify and report aggressive histological variants of differentiated thyroid cancer (e.g., tall cell, columnar cell, and hobnail variants of papillary thyroid carcinoma; widely invasive follicular thyroid carcinoma). This review analyzes the historical evolution of these entities and highlights unresolved issues with respect to the diagnostic criteria for these tumors.
目前的临床指南建议病理学家识别和报告分化型甲状腺癌的侵袭性组织学变异型（例如，甲状腺乳头状癌的高柱状细胞、柱状细胞和鞋钉样变异型；广泛浸润性滤泡状甲状腺癌）。本文分析了这些肿瘤的历史演变，并强调了这些肿瘤的诊断标准方面尚未解决的问题。
