Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
Ultrasound Med Biol. 2020 Jun;46(6):1373-1379. doi: 10.1016/j.ultrasmedbio.2020.02.016. Epub 2020 Mar 30.
The aim of the study described here was to determine whether vascularity patterns on Doppler ultrasonography (US) differentiate benign and malignant thyroid nodules with the intermediate suspicion pattern based on the 2015 American Thyroid Association guidelines. A total of 411 benign or malignant thyroid nodules from 406 patients with intermediate-suspicion US features were retrospectively collected. Univariate and multivariate logistic regression analyses with the generalized estimating equation were used to identify factors predicting malignancy, and odds ratios with 95% confidence intervals were calculated. The vascularity patterns significantly differed between the benign (353 of 411, 85.9%) and malignant (58 of 411, 14.1%) nodules (p = 0.005). Only intranodular vascularity was significantly associated with malignancy on univariate analysis (p = 0.006) and was an independent predictor of malignancy on multivariate analysis (p = 0.004). In conclusion, intranodular vascularity on Doppler US may be useful for predicting malignancy in thyroid nodules with the intermediate-suspicion pattern.
本研究旨在确定基于 2015 年美国甲状腺协会指南，多普勒超声（US）的血管模式是否可区分中间可疑模式的良性和恶性甲状腺结节。共回顾性收集了 406 例具有中间可疑 US 特征的患者的 411 个良性或恶性甲状腺结节。使用广义估计方程进行单因素和多因素逻辑回归分析，以确定预测恶性肿瘤的因素，并计算比值比及其 95%置信区间。良性（411 个中的 353 个，85.9%）和恶性（411 个中的 58 个，14.1%）结节的血管模式有显著差异（p=0.005）。单因素分析显示，仅结节内血管与恶性肿瘤显著相关（p=0.006），多因素分析显示，结节内血管是恶性肿瘤的独立预测因素（p=0.004）。总之，多普勒 US 的结节内血管可能有助于预测中间可疑模式的甲状腺结节的恶性肿瘤。
