Dr Zhuowei Yu, Shanghai Institute of Geriatrics and Gerontology, Shanghai Key Laboratory of Clinical Geriatrics, Department of Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Shanghai Medical College, Fudan University, 221 West Yan An Road, Shanghai 200040, P.R. China, Tel: 86-21-62483180 Fax: 86-21-62484981 Email:
J Nutr Health Aging. 2020;24(4):412-422. doi: 10.1007/s12603-020-1343-2.
Myokine Irisin has been proposed to regulate metabolic homeostasis, which is related to chronic diseases or physical activity. However, whether irisin levels in paired cerebrospinal fruid (CSF), plasma and their ratio of inpatients, could use as biomarkers, and be independently related to the varying physical dysfunction, muscle wasting severity and chronic diseases with varying severe degrees, remain largely elusive.
We conducted an observational study to assess the independent associations between irisin levels in paired cerebrospinal fruid (CSF), plasma and their ratio, and the independence in activities of daily life (ADLs), muscle wasting severity and chronic diseases with varying severe degrees among elderly Chinese in-patient subjects.
Among 217 inpatients in surgery wards with a mean age of 68.07 years (±15.94years), 31.3% of women and 68.7% of men were included in the study. Bivariate correlation analysis showed that Log transformed CSF and plasma irisin levels and their ratio were potential associated with age, fat%, muscle wasting time, ADLs, number of multimorbidity, the severity of bone mass loss and anemia. Regression models analysis indicated that CSF and plasma irisin levels and their ratio in inpatient individuals were independently associated with the independence in ADLs. Plasma irisin levels were independently related to the change of muscle wasting use.
Collectively, the evaluation of paired plasma and CSF irisin levels, and their ratio in in-patient individuals is intriguing candidates for the susceptibility of the independence in ADLs. Plasma irisin levels were positively associated with indepedence in ADLs, negatively related to muscle wasting severity, and could use as biomarkers for muscle wasting severity.
肌因子鸢尾素被认为可以调节代谢稳态，这与慢性疾病或身体活动有关。然而，住院患者的配对脑脊液（CSF）、血浆中的鸢尾素水平及其比值，是否可以作为生物标志物，且与不同程度的身体功能障碍、肌肉消耗严重程度和不同严重程度的慢性疾病独立相关，仍很大程度上不清楚。
我们进行了一项观察性研究，以评估配对脑脊液（CSF）、血浆中的鸢尾素水平及其比值与日常生活活动（ADLs）独立性、肌肉消耗严重程度和不同严重程度慢性疾病之间的独立关联，这些关联存在于中国老年住院患者中。
在平均年龄为 68.07 岁（±15.94 岁）的 217 名外科病房住院患者中，31.3%为女性，68.7%为男性。双变量相关分析显示，Log 转化的 CSF 和血浆鸢尾素水平及其比值与年龄、脂肪%、肌肉消耗时间、ADLs、多种合并症数量、骨量丢失严重程度和贫血有关。回归模型分析表明，住院患者的 CSF 和血浆鸢尾素水平及其比值与 ADLs 的独立性独立相关。血浆鸢尾素水平与肌肉消耗的变化独立相关。
总之，对住院患者的配对血浆和 CSF 鸢尾素水平及其比值的评估是 ADLs 独立性易感性的有趣候选标志物。血浆鸢尾素水平与 ADLs 的独立性呈正相关，与肌肉消耗的严重程度呈负相关，可作为肌肉消耗严重程度的生物标志物。
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