Sesti G, Andreozzi F, Fiorentino T V, Mannino G C, Sciacqua A, Marini M A, Perticone F
Dipartimento Scienze Mediche e Chirurgiche, Università "Magna-Græcia" di Catanzaro, Viale Europa, 88100, Catanzaro, Italy,
Acta Diabetol. 2014 Oct;51(5):705-13. doi: 10.1007/s00592-014-0576-0. Epub 2014 Mar 12.
Irisin, a novel myokine, was proposed to be able to regulate glucose homeostasis and obesity in mice. Whether irisin levels are associated with cardio-metabolic variables, insulin sensitivity, and vascular atherosclerosis in humans remain unsettled. To determine the associations between circulating irisin levels, cardio-metabolic variables, insulin sensitivity, and common carotid intima-media thickness (IMT), an indicator of vascular atherosclerosis, a cross-sectional evaluation of circulating irisin levels and cardio-metabolic variables in 192 White adults was conducted. Insulin sensitivity and insulin clearance were assessed by euglycemic-hyperinsulinemic clamp. Common carotid IMT was measured by ultrasound. After adjusting for age and gender, irisin levels were positively correlated with body fat mass (r = 0.12, P < 0.05), fasting (r = 0.17, P < 0.01), 2 h post-load insulin (r = 0.15, P < 0.02) levels, and IMT (r = 0.29, P < 0.0001) and were negatively correlated with insulin-stimulated glucose disposal (r = -0.18, P = 0.007), Matsuda index (r = -0.13, P < 0.04), disposition index (r = -0.278, P < 0.0001), and insulin clearance (r = -0.26, P < 0.0001). After adjusting for age, gender, and BMI, individuals in the highest tertile of irisin levels exhibited higher body fat mass (P < 0.01), fasting (P < 0.05), 2 h post-load (P < 0.01) insulin levels, carotid IMT (P < 0.001), lower insulin-stimulated glucose disposal (P < 0.001), Matsuda index (P < 0.01), disposition index (P < 0.01), and insulin clearance (P < 0.001) as compared with subjects in the lowest tertile of circulating irisin levels. Irisin is inversely associated with insulin sensitivity and positively associated with carotid IMT in humans, suggesting either increased release by adipose/muscle tissue in response to deterioration of insulin sensitivity or a compensatory increase in irisin to overcome an underlying irisin resistance.
鸢尾素是一种新型的肌动蛋白，被认为能够调节小鼠体内的葡萄糖稳态和肥胖。鸢尾素水平与人类心血管代谢变量、胰岛素敏感性和血管动脉粥样硬化之间是否存在关联仍未明确。为了确定循环鸢尾素水平、心血管代谢变量、胰岛素敏感性与作为血管动脉粥样硬化指标的颈总动脉内膜中层厚度（IMT）之间的关联，对192名白人成年人的循环鸢尾素水平和心血管代谢变量进行了横断面评估。通过正常血糖高胰岛素钳夹技术评估胰岛素敏感性和胰岛素清除率。通过超声测量颈总动脉IMT。在调整年龄和性别后，鸢尾素水平与体脂量（r = 0.12，P < 0.05）、空腹（r = 0.17，P < 0.01）、负荷后2小时胰岛素（r = 0.15，P < 0.02）水平以及IMT（r = 0.29，P < 0.0001）呈正相关，与胰岛素刺激的葡萄糖处置（r = -0.18，P = 0.007）、松田指数（r = -0.13，P < 0.04）、处置指数（r = -0.278，P < 0.0001）和胰岛素清除率（r = -0.26，P < 0.0001）呈负相关。在调整年龄、性别和BMI后，鸢尾素水平处于最高三分位数的个体与循环鸢尾素水平处于最低三分位数的个体相比，表现出更高的体脂量（P < 0.01）、空腹（P < 0.05）、负荷后2小时（P < 0.01）胰岛素水平、颈动脉IMT（P < 0.001），更低的胰岛素刺激的葡萄糖处置（P < 0.001）、松田指数（P < 0.01）、处置指数（P < 0.01）和胰岛素清除率（P < 0.001）。在人类中，鸢尾素与胰岛素敏感性呈负相关，与颈动脉IMT呈正相关，这表明可能是脂肪/肌肉组织因胰岛素敏感性恶化而增加释放鸢尾素，或者是鸢尾素的代偿性增加以克服潜在的鸢尾素抵抗。
