Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Department of Laboratory Medicine, "P. Giaccone" University Hospital, Palermo, Italy.
Rejuvenation Res. 2020 Dec;23(6):476-484. doi: 10.1089/rej.2019.2299. Epub 2020 May 11.
This article shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semisupercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semisupercentenarians and supercentenarians. Different studies have been published on supercentenarians, but to the best of our knowledge, this is the only concerning two sisters and the most detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality.
本文展示了两位特殊的兄弟姐妹——迪加（超级百岁老人）和菲利帕（准超级百岁老人）·卡梅莱里的人口统计学、临床、病史、认知和功能数据，以及生化、遗传和表观遗传参数。本研究的目的是为半超级百岁老人和超级百岁老人所代表的极端表型提供新的见解。已经有不同的研究发表在超级百岁老人身上，但据我们所知，这是唯一涉及到两位姐妹的研究，也是从表型角度来看最详细的研究。我们的发现与以下观点一致，即超级百岁老人对与年龄相关的疾病的相对抵抗力逐渐增强，接近人类功能储备的极限，从而成功应对急性死亡原因。更有趣的是，我们的数据与炎症和氧化应激预测百岁老人死亡率的观点一致，并对其进行了扩展。
