Department of Immunology and Rheumatology, Medical University Hannover, Germany.
Department of Rheumatology, Vamed-Ostseeklinik, Damp, Germany.
Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1127-1131. Epub 2020 Mar 28.
To study the association between the presence of antibodies against CD74 and structural damage in the sacroiliac joints and spine in patients with axial spondyloarthritis (axSpA).
Antibodies against CD74 were measured in the sera of patients with axSpA from 2 cohorts: 1. An observational cohort from Damp in Northern Germany and 2. from a clinical trial (ENRADAS), in which the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) had been evaluated by two readers blinded to the time point at baseline and two years later. The presence of antibodies against CD74 was correlated with the presence and grade of radiographic sacroiliitis in the observational cohort, and with baseline mSASSS in the ENRADAS cohort.
The sensitivity of IgA anti-CD74 antibodies for axSpA was 50% in the Damp cohort and 42% in ENRADAS. The presence of IgA antibodies against CD74 was associated with a higher grade of sacroiliitis (observational cohort) and a higher baseline mSASSS in the ENRADAS cohort.
IgA antibodies against CD74 are not only markers of AS, but are associated with structural damage development in the sacroiliac joints and in the spine.
研究抗 CD74 抗体在中轴型脊柱关节炎（axSpA）患者骶髂关节和脊柱结构损伤中的相关性。
在来自两个队列的 axSpA 患者血清中测量抗 CD74 抗体：1. 来自德国北部 Damp 的观察性队列，2. 来自临床试验（ENRADAS），其中由两名对基线和两年后时间点均不知情的读者评估改良 Stoke 强直性脊柱炎脊柱评分（mSASSS）。在观察性队列中，将抗 CD74 抗体的存在与放射学骶髂关节炎的存在和严重程度相关联，在 ENRADAS 队列中与基线 mSASSS 相关联。
Damp 队列中 IgA 抗 CD74 抗体对 axSpA 的敏感性为 50%，在 ENRADAS 队列中为 42%。IgA 抗 CD74 抗体的存在与骶髂关节炎严重程度更高（观察性队列）和 ENRADAS 队列中基线 mSASSS 更高相关。
IgA 抗 CD74 抗体不仅是 AS 的标志物，而且与骶髂关节和脊柱的结构损伤发展相关。
