Department of Psychiatry, University of California San Francisco, San Francisco, California.
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Hum Brain Mapp. 2020 Jul;41(10):2846-2861. doi: 10.1002/hbm.24981. Epub 2020 Apr 3.
This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band-dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus with and without hearing loss.
这项研究检查了慢性耳鸣患者以及听力正常和受损个体的神经振荡的全球静息态功能连接。我们检验了这样一个假设，即不同的神经振荡网络参与了有和没有听力损失的耳鸣。在有和没有听力损失的两组耳鸣患者中，我们都发现了多个与频率带相关的、增加和减少的全局功能连接的区域。我们还发现，由耳鸣严重程度的耳鸣功能指数评估的听觉域，与听觉和非听觉区域的全局功能连接都有关联。这些发现为针对有和没有听力损失的耳鸣治疗提供了候选生物标志物，以用于目标和监测治疗。
