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脉冲磁场对肿瘤性C3H/Bi雌性小鼠的影响。

Effect of a pulsed magnetic field on tumoral C3H/Bi female mice.

作者信息

Bellossi A, Desplaces A, Morin R

机构信息

Laboratoire de Biophysique, Faculté de Médecine, Rennes, France.

出版信息

Cancer Biochem Biophys. 1988 Jul;10(1):59-66.

PMID:3224332
Abstract

Female C3H/Bi mice develop spontaneous viral mammary carcinoma which can metastasize to the lungs. Two hundred and forty tumoral mice were either exposed to a toroïdal pulsed magnetic field, 12 Hz, 100 Hz or 460 Hz in frequency or used as controls. The exposure was mainly done 10 min. a day, 3 days a week, or 30 minutes once a week from about 2 to 3 weeks after the appearance of the tumors until death. In comparison with the controls, the exposed mice showed lighter spleens and lungs; this last observation could mean fewer pulmonary metastases. The weight of the tumors has been found lighter for 460 Hz MF, not changed for 100 Hz MF, heavier for 12 Hz MF, but lifespans were not altered by the exposure.

摘要

雌性C3H/Bi小鼠会自发形成病毒性乳腺癌,且这种癌症会转移至肺部。240只患肿瘤的小鼠被分别暴露于频率为12赫兹、100赫兹或460赫兹的环形脉冲磁场中,或用作对照。暴露主要在肿瘤出现后约2至3周直至死亡期间进行,每天10分钟,每周3天,或每周一次30分钟。与对照组相比,暴露组小鼠的脾脏和肺部较轻;最后这一观察结果可能意味着肺转移较少。已发现460赫兹磁场下肿瘤重量较轻,100赫兹磁场下肿瘤重量不变,12赫兹磁场下肿瘤重量较重,但暴露并未改变小鼠的寿命。

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