Gao Yang, Xu Suyun, Shen Yifeng, Liao Tingting, Hu Shiruo, Zhou Shan, Chen Qiu
Hospital of Chengdu University of Traditional Chinese Medicine, PR China.
Medicine (Baltimore). 2020 Apr;99(14):e19683. doi: 10.1097/MD.0000000000019683.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women and can lead to serious social burdens associated with various reproductive and metabolic abnormalities. Studies have demonstrated that metformin can reduce liver glucose in PCOS, lower testosterone levels and increase peripheral insulin sensitivity. There has been also evidence suggesting acupuncture may influence ovulation (release of the egg) by affecting levels of various hormones. We will conduct a systematic review and meta-analysis is to compare the efficacy and safety of metformin with or without acupuncture in PCOS.
We will search publications from Web of Science, PubMed, Science Direct, Wan Fang Data Knowledge Service Platform, Chinese Biomedical Literature Database (CBM), Chinese Scientific Journal Database (VIP database), China National Knowledge Infrastructure (CNKI) and EMBASE, which should be published from inception to February 2020. Two researchers will independently perform the selection of the studies, data extraction, and synthesis. The Cochrane Risk of Bias Tool will be used to evaluate the risk of bias of the randomized controlled trials. Statistical analysis will be performed by using the Cochrane Review Manager (RevMan 5.3) software. The I test will be used to identify the extent of heterogeneity. We will use the Egger funnel chart to evaluate possible publication biases, in addition, when possible we will perform a subgroup/meta-regression analysis. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
This study will systematically evaluate the efficacy and safety of Metformin combined with acupuncture in the treatment of PCOS, thus providing evidence to the clinical application of this combination therapy. The results will be published in a peer-reviewed journal.
多囊卵巢综合征（PCOS）是女性常见的内分泌紊乱疾病，可导致与各种生殖和代谢异常相关的严重社会负担。研究表明，二甲双胍可降低PCOS患者的肝脏葡萄糖水平，降低睾酮水平并提高外周胰岛素敏感性。也有证据表明针灸可能通过影响各种激素水平来影响排卵（卵子释放）。我们将进行一项系统评价和荟萃分析，以比较二甲双胍联合或不联合针灸治疗PCOS的疗效和安全性。
我们将检索Web of Science、PubMed、Science Direct、万方数据知识服务平台、中国生物医学文献数据库（CBM）、中文科技期刊数据库（维普数据库）、中国知网（CNKI）和EMBASE自创建至2020年2月发表的文献。两名研究人员将独立进行研究选择、数据提取和合成。将使用Cochrane偏倚风险工具评估随机对照试验的偏倚风险。将使用Cochrane系统评价软件（RevMan 5.3）进行统计分析。将使用I检验来识别异质性程度。我们将使用Egger漏斗图评估可能的发表偏倚，此外，如有可能，我们将进行亚组/荟萃回归分析。将根据推荐分级的评估、制定和评价（GRADE）来评估证据的强度。
本研究将系统评价二甲双胍联合针灸治疗PCOS的疗效和安全性，从而为这种联合治疗的临床应用提供证据。结果将发表在同行评审期刊上。
