在过度增殖的小鼠表皮中，昼夜节律受到抑制。

Circadian rhythms are suppressed in hyperproliferative mouse epidermis.

作者信息

Brown W R, Furukawa R D, Ramsay C A

机构信息

Department of Medicine, University of Toronto, Ontario, Canada.

出版信息

Cell Tissue Kinet. 1988 May;21(3):159-67. doi: 10.1111/j.1365-2184.1988.tb00854.x.

DOI:10.1111/j.1365-2184.1988.tb00854.x

PMID:3224364

Abstract

We examined the chronically hyperproliferative epidermis of the asebia (ab/ab) mouse for circadian rhythms in cell proliferation and in the rate of DNA synthesis, which is related to S phase duration. The curve for the circadian rhythm in cell proliferation for asebia epidermis was suppressed and distorted in comparison to that for BALB/cJ epidermis and in comparison to a composite curve produced by averaging the results from ten other published studies.

摘要

我们研究了无皮脂（ab/ab）小鼠慢性增生性表皮的细胞增殖昼夜节律以及与S期持续时间相关的DNA合成速率。与BALB/cJ表皮相比，以及与通过对其他十项已发表研究结果进行平均得出的复合曲线相比，无皮脂表皮细胞增殖的昼夜节律曲线受到抑制且发生了畸变。