Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT 06511, USA.
Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT 06511, USA.
Cell. 2020 Apr 2;181(1):7. doi: 10.1016/j.cell.2020.02.033.
The discovery of the strikingly rapid and robust antidepressant effects of r/s-ketamine for the treatment of antidepressant-resistant symptoms of depression has led to new insights into the biology of antidepressants and the FDA approval of its s-isomer, Esketamine (Spravato), the first mechanistically new treatment for depression in over 60 years. To view this Bench to Bedside, open or download the PDF.
r/s-氯胺酮治疗抗抑郁药抵抗性抑郁症状的显著快速和强效抗抑郁作用的发现，为抗抑郁药的生物学和 FDA 批准其 S-对映体依他佐辛（Spravato），即 60 多年来首个新型抗抑郁机制药物带来了新的认识。要查看本期从基础到临床，请打开或下载 PDF。
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