Graduate School of Health Sciences, Dokuz Eylül University, Izmir, Turkey.
School of Physical Therapy and Rehabilitation, Dokuz Eylül University, Izmir, Turkey.
Gait Posture. 2020 May;78:60-64. doi: 10.1016/j.gaitpost.2020.02.018. Epub 2020 Feb 26.
Cystic Fibrosis (CF), affecting functional exercise capacity generally measured by submaximal exercise test such as 6min walk test, is a progressive, autosomal recessive and metabolic disorder. Three-axis accelerometers, which are used during gait, are an easy way to assess gait parameters in patients and healthy individuals. Gait parameters were significantly associated with clinical outcomes of COPD. However, the association between gait parameters and clinical outcomes in children with CF is unclear.
Do clinical outcomes in CF have an important role in determining gait parameters?.
Twenty-one CF and 21 healthy subjects participated in this case-control study. Body composition was evaluated using Tanita-BC 418. Respiratory and knee extension muscle strengths were assessed. Functional exercise capacity was evaluated using the 6-min walk test (6MWT). Spatiotemporal gait parameters were evaluated using a validated wireless inertial sensing device (G-Sensor, BTS Bioengineering S.p.A., Italy) during the 6MWT and 7-meter gait test.
MIP, the distance of 6MWT, and stride length were significantly lower in the CF group compare to healthy children (p<0.05). Gait speed and functional exercise capacity, cadence and functional exercise capacity, quadriceps muscle strength, FEV1, fat-free mass were found to be correlated in CF patients (p<0.05).
The aerobic capacity and gait parameters were affected in CF patients with mild disease severity in our study. Clinical outcomes were associated with gait parameters in CF patients. This is the first study to use the 3-axis accelerometer to evaluate functional exercise capacity and gait parameters of CF and healthy children. A three-axis accelerometer can be used to assess functional exercise capacity and gait parameters in CF patients at the clinics.
囊性纤维化（CF）影响一般通过 6 分钟步行测试等亚最大运动测试来测量的功能性运动能力，是一种进行性、常染色体隐性和代谢紊乱的疾病。在步态期间使用的三轴加速度计是评估患者和健康个体步态参数的一种简单方法。步态参数与 COPD 的临床结果显著相关。然而，CF 患儿的步态参数与临床结果之间的关系尚不清楚。
CF 的临床结果在确定步态参数方面是否具有重要作用？
21 名 CF 患者和 21 名健康对照者参与了这项病例对照研究。使用 Tanita-BC418 评估身体成分。评估呼吸和膝关节伸展肌力。使用 6 分钟步行测试（6MWT）评估功能性运动能力。使用经过验证的无线惯性感应装置（G-Sensor，BTS Bioengineering S.p.A.，意大利）在 6MWT 和 7 米步行测试期间评估时空步态参数。
与健康儿童相比，CF 组的 MIP、6MWT 距离和步长明显较低（p<0.05）。在 CF 患者中，步态速度和功能性运动能力、步频和功能性运动能力、股四头肌力量、FEV1、去脂体重呈正相关（p<0.05）。
在本研究中，我们发现轻度疾病严重程度的 CF 患者的有氧运动能力和步态参数受到影响。临床结果与 CF 患者的步态参数相关。这是第一项使用三轴加速度计评估 CF 和健康儿童的功能性运动能力和步态参数的研究。三轴加速度计可用于在临床评估 CF 患者的功能性运动能力和步态参数。
