Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057 Rostock, Germany.
Medical Biology and Electron Microscopy Center, Rostock University Medical Center, Strempelstraße 14, 18057 Rostock, Germany.
Cells. 2020 Mar 31;9(4):843. doi: 10.3390/cells9040843.
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. During the last decade, the model of toxic demyelination induced by cuprizone has become more and more popular, and it has contributed substantially to our understanding of distinct yet important aspects of the MS pathology. Here, we aim to provide a practical guide on how to use the cuprizone model and which pitfalls should be avoided.
多发性硬化症（MS）是一种中枢神经系统的慢性炎症性脱髓鞘疾病。有多种具有不同疾病特定特征的临床前模型可用于研究 MS 的发病机制并开发新的治疗方法。在过去十年中，由铜缺乏诱导的脱髓鞘模型变得越来越流行，它为我们理解 MS 病理学的不同但重要的方面做出了重要贡献。在这里，我们旨在提供一份关于如何使用铜缺乏诱导的脱髓鞘模型以及应避免哪些陷阱的实用指南。
