Abendschein D, Seacord L M, Nohara R, Sobel B E, Jaffe A S
Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110.
Clin Cardiol. 1988 Oct;11(10):661-4. doi: 10.1002/clc.4960111002.
To determine the sensitivity and specificity of assays of isoforms of the MM isoenzyme of creatine kinase (CK) and MB-CK for the diagnosis or exclusion of acute myocardial infarction in plasma samples obtained at the time of presentation to the emergency room of patients with suspected myocardial infarction, 50 patients in whom the diagnosis was ultimately established and 31 in whom infarction was ultimately excluded were evaluated. Of the 50 patients in whom infarction was ultimately established, 47 had an increased ratio of the MM3 to the MM1 isoform or elevated MB-CK in the plasma sample initially available. The specificity of the approach was 77%, sensitivity 94%. The availability of rapid assays for MM-CK isoforms and for MB-CK should facilitate determination of the presence or absence of acute myocardial injury sufficiently promptly so that decisions regarding treatment can be made optimally.
为了确定肌酸激酶（CK）MM同工酶亚型和MB-CK检测在诊断或排除疑似心肌梗死患者就诊于急诊室时所采集血浆样本中的急性心肌梗死方面的敏感性和特异性，对最终确诊的50例患者和最终排除梗死的31例患者进行了评估。在最终确诊梗死的50例患者中，47例在最初可得的血浆样本中MM3与MM1同工酶比值升高或MB-CK升高。该方法的特异性为77%，敏感性为94%。MM-CK同工酶和MB-CK快速检测方法的可用性应能足够迅速地促进确定急性心肌损伤的有无，从而能够做出最佳的治疗决策。
