Spampinato Simona Federica, Caruso Grazia Ilaria, De Pasquale Rocco, Sortino Maria Angela, Merlo Sara
Department of Biomedical and Biotechnological Sciences, Section of Pharmacology University of Catania, 95123 Catania, Italy.
Ph.D. Program in Biotechnologies, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Pharmaceuticals (Basel). 2020 Apr 1;13(4):60. doi: 10.3390/ph13040060.
Chronic wounds often occur in patients with diabetes mellitus due to the impairment of wound healing. This has negative consequences for both the patient and the medical system and considering the growing prevalence of diabetes, it will be a significant medical, social, and economic burden in the near future. Hence, the need for therapeutic alternatives to the current available treatments that, although various, do not guarantee a rapid and definite reparative process, appears necessary. We here analyzed current treatments for wound healing, but mainly focused the attention on few classes of drugs that are already in the market with different indications, but that have shown in preclinical and few clinical trials the potentiality to be used in the treatment of impaired wound healing. In particular, repurposing of the antiglycemic agents dipeptidylpeptidase 4 (DPP4) inhibitors and metformin, but also, statins and phenyotin have been analyzed. All show encouraging results in the treatment of chronic wounds, but additional, well designed studies are needed to allow these drugs access to the clinics in the therapy of impaired wound healing.
由于伤口愈合受损，慢性伤口常发生于糖尿病患者中。这对患者和医疗系统都有负面影响，并且考虑到糖尿病患病率的不断上升，在不久的将来，这将成为一个重大的医疗、社会和经济负担。因此，有必要寻找替代当前可用治疗方法的治疗手段，尽管目前的治疗方法多种多样，但并不能保证快速且确定的修复过程。我们在此分析了当前用于伤口愈合的治疗方法，但主要关注了几类已上市的药物，这些药物有不同的适应症，并且在临床前和少数临床试验中已显示出用于治疗受损伤口愈合的潜力。特别是，我们分析了抗血糖药物二肽基肽酶4（DPP4）抑制剂和二甲双胍的重新利用，还有他汀类药物和苯妥英。所有这些药物在慢性伤口治疗中均显示出令人鼓舞的结果，但还需要更多精心设计的研究，以便这些药物能够用于受损伤口愈合的临床治疗。
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