犬瘟热病毒感染小鼠诱导的高胰岛素血症及其与肥胖出现的相关性。

Hyperinsulinemia induced by canine distemper virus infection of mice and its correlation with the appearance of obesity.

Bernard A, Zwingelstein G, Meister R, Wild T F

Unité de Virologie Fondamentale et Appliquée, INSERM U.51, CNRS UA 613 Lyon, France.

Comp Biochem Physiol B. 1988;91(4):691-6. doi: 10.1016/0305-0491(88)90193-9.

Abstract

Weanling Swiss mice surviving an acute infection with canine distemper virus were persistently infected. Among these mice, up to 30% had hyperinsulinemia and this was followed by an obesity syndrome. 2. Analysis of the lipid composition of various organs revealed that compared to control animals, the obese had an accumulation of triglycerides in both liver and adipose tissue. 3. Studies on the lipid metabolism using a number of radioactive lipid precursors showed a specific accumulation of the triglycerides of the obese animals. 4. A decrease of lipogenesis was observed in white adipose tissue of obese mice. Glycogenesis and serum glucose levels were unaffected during obesity. 5. The model of canine distemper virus-induced obesity is compared with other experimental models.

摘要

断奶的瑞士小鼠在感染犬瘟热病毒急性感染后存活下来，出现了持续性感染。在这些小鼠中，高达30%有高胰岛素血症，随后出现肥胖综合征。2. 对各种器官脂质成分的分析表明，与对照动物相比，肥胖小鼠的肝脏和脂肪组织中都有甘油三酯的积累。3. 使用多种放射性脂质前体对脂质代谢进行的研究表明，肥胖动物的甘油三酯有特异性积累。4. 在肥胖小鼠的白色脂肪组织中观察到脂肪生成减少。肥胖期间糖原生成和血清葡萄糖水平未受影响。5. 将犬瘟热病毒诱导的肥胖模型与其他实验模型进行了比较。