神经母细胞瘤细胞与少突胶质细胞的相互作用由神经细胞黏附分子介导。

Neuroblastoma cell-oligodendrocyte interaction is mediated by neural cell adhesion molecules.

作者信息

Bhat S, Silberberg D H

机构信息

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.

出版信息

Dev Neurosci. 1988;10(4):231-5. doi: 10.1159/000111973.

DOI:10.1159/000111973

PMID:3224563

Abstract

The role of neural cell adhesion molecule (NCAM) in the interaction between neurons and oligodendrocytes was studied using N2A neuroblastoma cells, which express only the 180,000 Mr NCAM and rat oligodendrocytes which express only 120,000 Mr NCAM. Oligodendrocytes bound to neuroblastoma cells, and the binding was inhibited by anti-NCAM, suggesting that NCAM is involved in oligodendrocyte-neuron interaction. The possible role of NCAM in myelination and remyelination is discussed.

摘要

利用仅表达180,000道尔顿神经细胞黏附分子（NCAM）的N2A神经母细胞瘤细胞和仅表达120,000道尔顿NCAM的大鼠少突胶质细胞，研究了NCAM在神经元与少突胶质细胞相互作用中的作用。少突胶质细胞与神经母细胞瘤细胞结合，且这种结合被抗NCAM抑制，这表明NCAM参与少突胶质细胞 - 神经元相互作用。文中还讨论了NCAM在髓鞘形成和髓鞘再生中的可能作用。