神经细胞黏附分子的最大组成部分NCAM-180在脱髓鞘的颤抖突变小鼠大脑中减少。

NCAM-180, the largest component of the neural cell adhesion molecule, is reduced in dysmyelinating quaking mutant mouse brain.

作者信息

Bhat S, Silberberg D H

机构信息

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104.

出版信息

Brain Res. 1988 Jun 14;452(1-2):373-7. doi: 10.1016/0006-8993(88)90042-x.

DOI:10.1016/0006-8993(88)90042-x

PMID:3401744

Abstract

To explore the role of the neural cell adhesion molecule (NCAM) in myelination and remyelination, we studied the developmental expression of various molecular forms of NCAM in dysmyelinating quaking mouse brain as compared with normal mouse brain. Normal mouse brain expressed the several molecular forms differentially during development. Quaking showed a marked reduction in the expression of NCAM-180, which represents the largest component of NCAM, in comparison with normal brain. This suggests that the defective myelin compaction in the quaking mutation may be the result of a deficiency of NCAM-180.

摘要

为了探究神经细胞黏附分子（NCAM）在髓鞘形成和髓鞘再生中的作用，我们研究了与正常小鼠脑相比，脱髓鞘的颤抖小鼠脑中NCAM各种分子形式的发育表达情况。正常小鼠脑在发育过程中差异表达几种分子形式。与正常脑相比，颤抖小鼠脑中代表NCAM最大成分的NCAM - 180的表达显著降低。这表明颤抖突变中髓鞘紧密化缺陷可能是NCAM - 180缺乏的结果。