胎盘哺乳动物起源之初的一个检查点悬念。
A checkpoint cliffhanger at the dawn of placental mammals.
作者信息
Dustin Michael L, Zenclussen Ana C
机构信息
Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom
Experimental Obstetrics and Gynecology, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany
出版信息
J Biol Chem. 2020 Apr 3;295(14):4381-4382. doi: 10.1074/jbc.H120.013307.
The PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips explore the distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance. This work provides a deeper understanding of how the immune system adapted to mammalian placental gestation and could be an important consideration in the development of new immune checkpoint therapies.
程序性死亡受体1（PD-1）配体PD-L1和PD-L2通常在细胞表面表达，在那里它们调节免疫系统的激活。然而，每种配体所起的具体作用尚不清楚。飞利浦团队利用定点诱变、表面等离子体共振和晶体学技术，探索了PD-L2的独特特征，并确定了与其出现相关的特定进化事件。这项工作为免疫系统如何适应哺乳动物胎盘妊娠提供了更深入的理解，并且可能是新免疫检查点疗法开发中的一个重要考量因素。
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