Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Sci Rep. 2020 Apr 3;10(1):5931. doi: 10.1038/s41598-020-62834-x.
The link between psoriasis and obstructive sleep apnea (OSA) has not been confirmed. We aimed to investigate the relationship between psoriasis and OSA. We conducted a systematic review and meta-analysis of case-control, cross-sectional, and cohort studies on the association between psoriasis and OSA. We searched MEDLINE and Embase for relevant studies on May 11, 2019. The Newcastle-Ottawa Scale was used to evaluate the risk of bias of included studies. We performed random-effects model meta-analysis to calculate pooled odds ratio (ORs) with 95% confidence intervals (CIs) for case-control and cross-sectional studies as well as pooled incidence rate ratio (IRR) with 95% CIs for cohort studies in association between psoriasis and OSA. A total of 4 case-control or cross-sectional studies and 3 cohort studies with a total of 5,840,495 subjects were included. We identified a significantly increased odds for OSA in psoriasis patients (pooled OR 2.60; 95% CI 1.07-6.32), and significantly increased risk for psoriasis in OSA patients (pooled IRR 2.52; 95% CI 1.89-3.36). In conclusion, our study identified a bidirectional association between psoriasis and OSA. Sleep quality should be inquired in patients with psoriasis. Respirologist consultation or polysomnography may be indicated for those presenting with night snoring, recurrent awaking, and excessive daytime sleepiness.
银屑病与阻塞性睡眠呼吸暂停（OSA）之间的联系尚未得到证实。我们旨在研究银屑病与 OSA 之间的关系。我们对关于银屑病与 OSA 之间关联的病例对照、横断面和队列研究进行了系统评价和荟萃分析。我们于 2019 年 5 月 11 日在 MEDLINE 和 Embase 上搜索了相关研究。使用纽卡斯尔-渥太华量表评估纳入研究的偏倚风险。我们使用随机效应模型荟萃分析，计算病例对照和横断面研究中汇总的优势比（OR）和 95%置信区间（CI），以及队列研究中汇总的发病率比（IRR）和 95%CI 用于评估银屑病与 OSA 之间的关联。共纳入了 4 项病例对照或横断面研究和 3 项队列研究，共有 5840495 名受试者。我们发现银屑病患者 OSA 的发生几率显著增加（汇总 OR 2.60；95%CI 1.07-6.32），OSA 患者发生银屑病的风险也显著增加（汇总 IRR 2.52；95%CI 1.89-3.36）。总之，我们的研究确定了银屑病与 OSA 之间的双向关联。应询问患有银屑病的患者的睡眠质量。对于出现夜间打鼾、反复觉醒和日间过度嗜睡的患者，可能需要进行呼吸科医生咨询或多导睡眠图检查。
