Pinto F, Amantini A, de Scisciolo G, Scaioli V, Guidi L, Frosini R
Institute of Neurology, University of Florence, Italy.
Eur Neurol. 1988;28(5):246-51. doi: 10.1159/000116277.
Neuro-ophthalmological assessment, including red-free light retinography, in conjunction with simultaneous visual evoked potential (VEP) and pattern electroretinogram (PERG) recordings were performed in 10 Friedreich's ataxia patients: 9 patients showed marked VEP abnormalities. Moderate PERG amplitude reduction, with normal latencies, was related to mild and scattered fiber loss revealed by red-free light retinography. The initial part of the visual pathways does not seem to be the main site of electrophysiological abnormalities as demonstrated by the greater extent and relative independence of VEP versus PERG alterations. Primary axonal degeneration of the optic nerve and tracts cannot account for all features of VEP abnormalities, thus implying some dysfunction in succeeding visual structures as well.
对10例弗里德赖希共济失调患者进行了神经眼科评估，包括无赤光视网膜造影，并同时记录视觉诱发电位（VEP）和图形视网膜电图（PERG）：9例患者显示出明显的VEP异常。PERG振幅中度降低，但潜伏期正常，这与无赤光视网膜造影显示的轻度和散在性纤维丢失有关。视觉通路的起始部分似乎不是电生理异常的主要部位，VEP改变的程度更大且相对独立于PERG改变，这证明了这一点。视神经和视束的原发性轴索变性不能解释VEP异常的所有特征，因此也意味着后续视觉结构也存在一些功能障碍。
