Kirkham T H, Coupland S G
Can J Neurol Sci. 1981 Nov;8(4):289-94. doi: 10.1017/s0317167100043407.
We made an electroretinographic (ERG) and visual evoked potential (VEP) study of 12 patients with Friedreich's ataxia whose diagnosis was established using the Quebec diagnostic criteria. ERGs and VEPs were elicited to the same stimulating conditions. Flash evoked luminance changes and pattern-specific evoked potentials to check and diamond stimuli were used. Statistical analysis of the data was made using independent sample t-tests. Significant VEP delays were present under all test conditions. The presence of significant interocular and interhemispheric delays as well as evidence of abnormal temporal dispersion of the VEP response suggest there to be both diffuse anterior visual system disease and retrochiasmal involvement in Friedreich's ataxia. The implicit times of the ERG b-waves were statistically within normal limits but the waveforms were of low amplitude and deformed and there were significant interocular implicit time differences. These ERG results suggest there are retinal conduction abnormalities in Friedreich's ataxia which possibly play a role in the genesis of the abnormal VEPs.
我们对12例经魁北克诊断标准确诊的弗里德赖希共济失调患者进行了视网膜电图（ERG）和视觉诱发电位（VEP）研究。在相同刺激条件下引出ERG和VEP。使用闪光诱发的亮度变化以及针对方格和菱形刺激的模式特异性诱发电位。采用独立样本t检验对数据进行统计分析。在所有测试条件下均存在显著的VEP延迟。显著的眼间和半球间延迟的存在以及VEP反应异常时间离散的证据表明，弗里德赖希共济失调存在弥漫性前视觉系统疾病和视交叉后受累。ERG b波的潜伏时间在统计学上在正常范围内，但波形振幅低且变形，并且存在显著的眼间潜伏时间差异。这些ERG结果表明，弗里德赖希共济失调存在视网膜传导异常，这可能在异常VEP的发生中起作用。
