College of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing, 210095, China.
Mol Biol Rep. 2020 May;47(5):4087-4091. doi: 10.1007/s11033-020-05414-6. Epub 2020 Apr 3.
Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use them to optimize the health benefits and avoid adverse effects is a major challenge. Estrogen is an indispensable hormone for proper biological functioning but is also implicated with the pathology of both the reproductive and non-reproductive tissues. Abnormal estrogen receptor signaling may increase the risk of development of a variety of diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant subtype in the colonic epithelium and confers the anti-tumor effect through various mechanisms. Many investigators have embarked on the search for the biological mechanisms by which estrogen and estrogen-like compounds may influence the pathogenesis of CRC. This review explores the recent findings on the therapeutic role of ERβ in the colonic epithelium as a prospective candidate for targeted endocrine therapy in CRC.
激素已成为临床内分泌学中一种有用的治疗方法，但如何利用它们来优化健康益处并避免不良反应是一个主要挑战。雌激素是正常生物学功能所必需的激素，但也与生殖和非生殖组织的病理学有关。异常的雌激素受体信号可能会增加多种疾病的发病风险，包括结直肠癌（CRC）。雌激素受体β（ERβ）是结肠上皮中的主要亚型，通过多种机制发挥抗肿瘤作用。许多研究人员已经开始探索雌激素和类雌激素化合物可能影响 CRC 发病机制的生物学机制。本文综述了 ERβ在结肠上皮中的治疗作用的最新发现，认为其是 CRC 靶向内分泌治疗的有前途的候选药物。
