Thomas Sumesh, van Dyk Jessie, Zein Hussein, Nettel Aguirre Alberto, Hendson Leonora, Church Paige, Banihani Rudaina, Asztalos Elizabeth
Foothills Medical Centre, University of Calgary, Calgary, AB, Canada.
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Acta Paediatr. 2020 Dec;109(12):2578-2585. doi: 10.1111/apa.15281. Epub 2020 Apr 20.
To compare composite outcomes of neonatal mortality or morbidity using a split-week gestational age (GA) model to completed weeks GA maturity at 23-26 weeks gestation.
This was a retrospective cohort study of infants born at 23-26 weeks GA. Outcomes using a split-week GA model defined as early (X, 0-3) and late (X, 4-6) with X being 23-26 weeks GA were compared to outcomes using completed weeks GA, with a similar comparison between the late split of the preceding week (X, 4-6) and early split of the subsequent week (X + 1, 0-3).
A total of 1345 infants were included in the study. Statistically significant differences were noted in outcomes between the early and late split of the gestational week at 24 (early vs late, 85.6% vs 73.0%), 25 (69.6% vs 56.6%) and 26 weeks (55.9% vs 37.4%), but not at 23 weeks GA (95.2% vs 94.5%). No statistically significant differences were noted between the late vs early part of the subsequent week (23, 4-6) vs (24, 0-3), and (24, 4-6) vs (25, 0-3) GA.
Neonatal outcome estimates using a split week model differs from that based on the use of completed weeks of gestational maturity.
使用分周胎龄（GA）模型比较23 - 26周妊娠时新生儿死亡或发病的综合结局与完整周数胎龄成熟度的情况。
这是一项对23 - 26周胎龄出生婴儿的回顾性队列研究。将使用分周GA模型（定义为早期（X，0 - 3）和晚期（X，4 - 6），其中X为23 - 26周GA）的结局与使用完整周数GA的结局进行比较，并对前一周的晚期划分（X，4 - 6）和后一周的早期划分（X + 1，0 - 3）进行类似比较。
该研究共纳入1345名婴儿。在24周（早期与晚期，85.6%对73.0%）、25周（69.6%对56.6%）和26周（55.9%对37.4%）的妊娠周早期和晚期划分的结局中发现有统计学显著差异，但在23周胎龄时未发现（95.2%对94.5%）。在随后一周的晚期与早期部分（23，4 - 6）对（24，0 - 3）以及（24，4 - 6）对（25，0 - 3）胎龄之间未发现统计学显著差异。
使用分周模型的新生儿结局估计与基于完整妊娠周成熟度的估计不同。
