血浆代谢型儿茶酚胺与原发性高血压患者心肌肥厚和心脏舒张功能有关。
Plasma metanephrins are associated with myocardial hypertrophy and cardiac diastolic function in patients with essential hypertension.
机构信息
Department of Cardiology, China-Japan Friendship Hospital, Beijing, China.
Department of Cardiology, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.
出版信息
Clin Invest Med. 2020 Apr 5;43(1):E22-E29. doi: 10.25011/cim.v43i1.33581.
PURPOSE
To explore the association between the sympathetic system activity and myocardial hypertrophy in patients with essential hypertension.
METHODS
A total of 84 essential hypertension inpatients were recruited from China-Japan Friendship Hospital between January 2019 and September 2019. Activity of sympathetic system was quantified by plasma metanephrines (MNs) levels. All subjects received an echocardiographic test.
RESULTS
The interventricular septum thickness (diastolic), left ventricular mass and left ventricular mass index increased significantly with plasma MNs quartiles, and plasma MNs were positively and significantly correlated with early diastolic transmitral flow velocity to early diastolic mitral annular tissue velocity.
CONCLUSIONS
In patients with essential hypertension, high level of plasma MNs associates with left ventricular hypertrophy and impaired diastolic function.
目的
探讨原发性高血压患者交感神经系统活性与心肌肥厚的关系。
方法
本研究于 2019 年 1 月至 9 月期间，选取中日友好医院的 84 例原发性高血压住院患者。通过测定血浆甲氧基肾上腺素（MNs）水平来量化交感神经系统的活性。所有患者均接受超声心动图检查。
结果
随着血浆 MNs 四分位区间的增加，室间隔厚度（舒张末期）、左心室质量和左心室质量指数均显著增加，且血浆 MNs 与舒张早期二尖瓣血流速度至舒张早期二尖瓣环组织速度呈正相关。
结论
在原发性高血压患者中，较高水平的血浆 MNs 与左心室肥厚和舒张功能障碍相关。
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