School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China; Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.
Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.
Am J Ophthalmol. 2020 Aug;216:99-109. doi: 10.1016/j.ajo.2020.03.031. Epub 2020 Apr 2.
We sought to investigate the bulbar conjunctival vascular responses in habitual contact lens (HCL) and non-contact lens (NCL) wearers after short-term lens wear and their relationships with ocular comfort.
A prospective, comparative before-and-after study.
Twenty-seven subjects (13 HCL and 14 NCL wearers) were enrolled. Microvasculature and microcirculation on the temporal bulbar conjunctiva were imaged at baseline and 0.5 and 6 hours after wearing contact lenses (1-Day Acuvue TruEye; base curve, 8.5 mm; power, -0.50 diopters) on both eyes. The measurements included vessel diameter (D), axial (VA), and cross-sectional (VS) blood flow velocities, blood flow volume (Q), and vessel density (Dbox) and complexity (D0). A Contact Lens User Experience (CLUE) questionnaire was used to assess ocular comfort.
No significant change (P > .05) was observed in D, VA, VS, Q, Dbox, and D0 in the HCL wearers after contact lens wear. By contrast, VA, VS, Q, Dbox, and D0 increased significantly after lens wear (after 0.5 and 6 hours) in NCL wearers compared with baseline (P < .05). Moreover, the changes from the baseline to 0.5 hours (VA, VS, and Dbox) and 6 hours (VA, VS, Q, Dbox, and D0) after contact lens wear in NCL wearers were significantly greater than that in HCL wearers (P < .05). The CLUE score 6 hours after lens wear was higher in HCL wearers than in NCL wearers (P < .05). It was also significantly correlated with VA, VS, and D0 after 6-hour lens wear in HCL wearers (P < .05).
This is the first study to reveal the relationship between ocular comfort and conjunctival vascular responses in habitual contact lens wearers.
我们旨在研究习惯性隐形眼镜（HCL）和非接触镜（NCL）佩戴者在短期佩戴隐形眼镜后的球结膜血管反应及其与眼部舒适度的关系。
前瞻性、对照前后研究。
共纳入 27 名受试者（13 名 HCL 佩戴者和 14 名 NCL 佩戴者）。在双眼佩戴隐形眼镜（1 天 Acuvue TruEye；基弧 8.5mm；屈光度-0.50 度）后 0.5 小时和 6 小时，对颞侧球结膜的微血管和微循环进行成像。测量指标包括血管直径（D）、轴向（VA）和横截面（VS）血流速度、血流体积（Q）、血管密度（Dbox）和复杂性（D0）。使用隐形眼镜使用者体验（CLUE）问卷评估眼部舒适度。
在 HCL 佩戴者佩戴隐形眼镜后，D、VA、VS、Q、Dbox 和 D0 均无显著变化（P >.05）。相比之下，在 NCL 佩戴者中，VA、VS、Q、Dbox 和 D0 在佩戴隐形眼镜后（0.5 和 6 小时后）均显著高于基线（P <.05）。此外，与 HCL 佩戴者相比，NCL 佩戴者在佩戴隐形眼镜后从基线到 0.5 小时（VA、VS 和 Dbox）和 6 小时（VA、VS、Q、Dbox 和 D0）的变化明显更大（P <.05）。HCL 佩戴者在佩戴隐形眼镜 6 小时后的 CLUE 评分高于 NCL 佩戴者（P <.05）。HCL 佩戴者在佩戴隐形眼镜 6 小时后，CLUE 评分与 VA、VS 和 D0 显著相关（P <.05）。
这是第一项揭示习惯性隐形眼镜佩戴者眼部舒适度与结膜血管反应之间关系的研究。
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