Hu L, Shu X P, Xu Y Y, Cheng J, Xu Z Q, Wang J H, Lyu F
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, China.
Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States.
Zhonghua Yan Ke Za Zhi. 2019 Feb 11;55(2):98-104. doi: 10.3760/cma.j.issn.0412-4081.2019.02.006.
To explore the changes of microcirculation of the bulbar conjunctiva after wearing the contact lens and the relationship between contact lens discomfort and bulbar conjunctiva microcirculation. Prospective cohort study. The postgraduate students from School of Ophthalmology & Optometry and School of Biomedical Engineering of Wenzhou Medical University were included in this prospective cohort study. The subjects wore soft contact lenses, and the right eye was selected as the experimental eye. The ocular surface disease index (OSDI) questionnaire, Schirmer I and tear break-up time tests were completed before and after wearing the contact lens, and the conjunctival blood flow velocity and microvascular network density were also assessed by using functional slit lamp biomicroscopy. The changes of the indicators after wearing the contact lens were observed and the correlation between the subjective feelings of the wearers and the microcirculation parameters of the bulbar conjunctiva and the main factors affecting the subjective feelings of the wearers were analyzed. Twenty-seven subjects were enrolled in the study, including 8 males and 19 females, aged (22.7±1.6) years. The OSDI score was 11.860± 7.783 before wearing the contact lens and 24.017±12.181 after wearing the contact lens. The comparison before and after wearing the contact lens was statistically significant (-4.356, 0.001). The conjunctival blood flow velocity was (0.534±0.132) mm/s before wearing the contact lens and (0.587±0.134) mm/s after wearing the contact lens. The comparison was statistically significant before and after wearing the lens (-2.076, 0.048). OSDI was positively correlated with blood flow velocity at 1 month after wearing the contact lens (correlation coefficient 0.383, 0.048). The test results of the independent variables in the generalized estimating equation model showed that time and blood flow velocity were statistically significant (0.05). The blood flow velocity of the bulbar conjunctiva was increased after wearing the contact lens, and the contact lens discomfort of the wearers was positively correlated with the blood flow velocity of the bulbar conjunctiva. -.
探讨佩戴隐形眼镜后球结膜微循环的变化以及隐形眼镜不适与球结膜微循环之间的关系。前瞻性队列研究。温州医科大学眼视光学院和生物医学工程学院的研究生被纳入这项前瞻性队列研究。受试者佩戴软性隐形眼镜，选取右眼作为实验眼。在佩戴隐形眼镜前后完成眼表疾病指数（OSDI）问卷、Schirmer I试验和泪膜破裂时间测试，并使用功能性裂隙灯显微镜评估结膜血流速度和微血管网络密度。观察佩戴隐形眼镜后各项指标的变化，分析佩戴者主观感受与球结膜微循环参数之间的相关性以及影响佩戴者主观感受的主要因素。本研究共纳入27名受试者，其中男性8名，女性19名，年龄（22.7±1.6）岁。佩戴隐形眼镜前OSDI评分为11.860±7.783，佩戴后为24.017±12.181。佩戴隐形眼镜前后比较差异有统计学意义（-4.356，0.001）。佩戴隐形眼镜前结膜血流速度为（0.534±0.132）mm/s，佩戴后为（0.587±0.134）mm/s。佩戴前后比较差异有统计学意义（-2.076，0.048）。佩戴隐形眼镜1个月后OSDI与血流速度呈正相关（相关系数0.383，0.048）。广义估计方程模型中自变量的检验结果显示时间和血流速度差异有统计学意义（0.05）。佩戴隐形眼镜后球结膜血流速度增加，佩戴者的隐形眼镜不适与球结膜血流速度呈正相关。 -
