对七个基因多态性与妊娠期糖尿病之间的关联进行调查：来自荟萃分析的证据。
Investigations of Associations between Seven Gene Polymorphisms and Gestational Diabetes Mellitus: Evidence From a Meta-Analysis.
机构信息
Department of Pregnancy Health, Huai'an Maternal and Child Health Hospital, Huai'an, China.
Department of Pregnancy Health, Huai'an Maternal and Child Health Hospital, Huai'an, China,
出版信息
Gynecol Obstet Invest. 2020;85(3):229-236. doi: 10.1159/000505453. Epub 2020 Apr 3.
BACKGROUND
Associations of polymorphisms in transcription factor 7 like 2 (TCF7L2), tumor necrosis factor-α (TNF-α), vitamin D receptor (VDR), and interleukin-10 with gestational diabetes mellitus (GDM) were already reported by several publications.
OBJECTIVES
The aim of this meta-analysis was to better clarify associations between these polymorphisms and GDM by combing the results of all relevant publications.
METHODS
Eligible publications were searched from Pubmed, Embase, WOS, and CNKI. We used Review Manager to combine the results of individual studies.
RESULTS
Thirty-nine studies were included in this study. Combined results revealed that TCF7L2 rs290487, TCF7L2rs7901695, TCF7L2rs7903146, TCF7L2 rs12255372, TNF-α rs1800629, and VDR FokI rs2228570 polymorphisms were all significantly associated with susceptibility to GDM in the total population. In subgroup analyses, we obtained similar positive findings for rs290487, rs7903146, rs1800629, and rs2228570 polymorphisms in Asians, and positive results were also observed for rs7901695, rs7903146, and rs12255372 polymorphisms in Caucasians.
CONCLUSIONS
Collectively, this meta-analysis proved that TCF7L2 rs290487, TCF7L2rs7901695, TCF7L2rs7903146, TCF7L2 rs12255372, TNF-α rs1800629, and VDR FokI rs2228570 polymorphisms may confer susceptibility to GDM in certain populations.
背景
转录因子 7 样 2（TCF7L2）、肿瘤坏死因子-α（TNF-α）、维生素 D 受体（VDR）和白细胞介素-10 的多态性与妊娠糖尿病（GDM）的关联已被多项出版物报道。
目的
本荟萃分析的目的是通过合并所有相关出版物的结果，更好地阐明这些多态性与 GDM 之间的关联。
方法
从 Pubmed、Embase、WOS 和 CNKI 中检索符合条件的文献。我们使用 Review Manager 合并个体研究的结果。
结果
共有 39 项研究纳入本研究。合并结果显示，TCF7L2 rs290487、TCF7L2rs7901695、TCF7L2rs7903146、TCF7L2 rs12255372、TNF-α rs1800629 和 VDR FokI rs2228570 多态性在总体人群中均与 GDM 的易感性显著相关。在亚组分析中，我们在亚洲人群中也得到了 rs290487、rs7903146、rs1800629 和 rs2228570 多态性的类似阳性发现，在白种人群中也观察到了 rs7901695、rs7903146 和 rs12255372 多态性的阳性结果。
结论
总的来说，这项荟萃分析证明 TCF7L2 rs290487、TCF7L2rs7901695、TCF7L2rs7903146、TCF7L2 rs12255372、TNF-α rs1800629 和 VDR FokI rs2228570 多态性可能在某些人群中导致 GDM 的易感性。
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