IMASL-CONICET, Universidad Nacional de San Luis, Ejército de Los Andes 950, 5700, San Luis, Argentina.
J Mol Evol. 2020 Jul;88(5):424-426. doi: 10.1007/s00239-020-09940-6. Epub 2020 Apr 4.
Here we propose that the upper bound marginal stability of proteins is a universal property that includes macro-molecular complexes and is not affected by molecular changes such as mutations and post-translational modifications. We theorize that its existence is a consequence of Afinsen's thermodynamic hypothesis rather than a result of an evolutionary process. This result enables us to conjecture that neutral evolution should also be, with respect to protein stability, a universal phenomenon.
在这里，我们提出蛋白质的上限边缘稳定性是一种普遍特性，包括大分子复合物，不受分子变化（如突变和翻译后修饰）的影响。我们推测它的存在是 Afinsen 热力学假设的结果，而不是进化过程的结果。这一结果使我们能够推测，就蛋白质稳定性而言，中性进化也应该是一种普遍现象。
