Department of Mechanical Engineering, Clemson University, Clemson, SC, 29634-0921, USA.
Department of Cardiology, Royal Children's Hospital, Parkville, Victoria, Australia.
J Cardiovasc Transl Res. 2021 Aug;14(4):782-789. doi: 10.1007/s12265-020-09993-4. Epub 2020 Apr 4.
We developed models of pulmonary artery (PA) size in Fontan patients as a function of age and body surface area (BSA) using linear regression and breakpoint analyses based on data from 43 Fontan patients divided into two groups: the extracardiac conduit (ECC) group (n = 24) and the non-ECC group (n = 19). Model predictions were compared against those of a non-Fontan control group (n = 18) and published literature. We observed strong positive correlations of the mean PA diameter with BSA (r = 0.9, p < 0.05) and age (r = 0.88, p < 0.05) in the ECC group. The absolute percentage differences between our BSA and age model predictions against published literature were less than 16% and 20%, respectively. Predicted PA size for Fontan patients was consistently smaller than the control group. These models may serve as useful references for clinicians and be utilized to construct 3D anatomic models that correspond to patient body size or age.
我们开发了基于线性回归和断点分析的肺动脉（PA）大小模型，以年龄和体表面积（BSA）为函数，该模型基于 43 名 Fontan 患者的数据，将患者分为两组：体外循环管道（ECC）组（n=24）和非 ECC 组（n=19）。我们将模型预测与非 Fontan 对照组（n=18）和已发表文献进行了比较。我们观察到 ECC 组中平均 PA 直径与 BSA（r=0.9，p<0.05）和年龄（r=0.88，p<0.05）之间存在很强的正相关关系。我们的 BSA 和年龄模型预测与已发表文献之间的绝对百分比差异分别小于 16%和 20%。Fontan 患者的预测 PA 大小始终小于对照组。这些模型可以作为临床医生的有用参考，并用于构建与患者体型或年龄相对应的 3D 解剖模型。
