Guazzi M, Polese A, Fiorentini C, Olivari M T, Magrini F
Am J Med Sci. 1977 Jan-Feb;273(1):63-9. doi: 10.1097/00000441-197701000-00006.
The purpose of the study was to evaluate the functional changes which may occur in the human hypertensive heart following treatment with beta-blocking agents. In 54 primary hypertensive men investigated in the control state and after three weeks of treatment with propranolol (320 mg/day) it was seen that: (a) beta-adrenergic blockade depresses the pre-ejection, and probably the ejection left ventricular function; (b) the former effect is unrelated to changes in peripheral circulation, while the latter result may be either potentiated or overcome, depending on the direction to which treatment shifts the vascular resistance; (c) variations of impedance, rather than of blood pressure, influence the ejection left ventricular function; and (d) withdrawal of the adrenergic support to the heart, due to beta-blockade, is probably the primary factor responsible for the abnormal ventricular adaptation to an augmented impedance.
该研究的目的是评估β受体阻滞剂治疗后人类高血压心脏可能发生的功能变化。在对54名原发性高血压男性进行的对照研究以及使用普萘洛尔（320毫克/天）治疗三周后发现：（a）β肾上腺素能阻滞会降低射血前期，可能还会降低左心室射血功能；（b）前一种效应与外周循环的变化无关，而后一种结果可能会增强或被克服，这取决于治疗使血管阻力改变的方向；（c）阻抗的变化而非血压的变化会影响左心室射血功能；（d）由于β受体阻滞导致心脏肾上腺素能支持撤离，可能是心室对增加的阻抗出现异常适应的主要因素。
