Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Phytother Res. 2020 Oct;34(10):2471-2492. doi: 10.1002/ptr.6700. Epub 2020 Apr 17.
Several corona viral infections have created serious threats in the last couple of decades claiming the death of thousands of human beings. Recently, corona viral epidemic raised the issue of developing effective antiviral agents at the earliest to prevent further losses. Natural products have always played a crucial role in drug development process against various diseases, which resulted in screening of such agents to combat emergent mutants of corona virus. This review focuses on those natural compounds that showed promising results against corona viruses. Although inhibition of viral replication is often considered as a general mechanism for antiviral activity of most of the natural products, studies have shown that some natural products can interact with key viral proteins that are associated with virulence. In this context, some of the natural products have antiviral activity in the nanomolar concentration (e.g., lycorine, homoharringtonine, silvestrol, ouabain, tylophorine, and 7-methoxycryptopleurine) and could be leads for further drug development on their own or as a template for drug design. In addition, a good number of natural products with anti-corona virus activity are the major constituents of some common dietary supplements, which can be exploited to improve the immunity of the general population in certain epidemics.
在过去的几十年里，有几种冠状病毒感染对人类造成了严重威胁，导致数千人死亡。最近，冠状病毒疫情引发了人们的关注，即尽快开发出有效的抗病毒药物，以防止进一步的损失。天然产物在药物开发过程中一直起着至关重要的作用，对抗各种疾病，这导致了对这些对抗冠状病毒的新药物的筛选。这篇综述主要关注那些对冠状病毒显示出良好效果的天然化合物。尽管抑制病毒复制通常被认为是大多数天然产物抗病毒活性的一般机制，但研究表明，一些天然产物可以与与毒力相关的关键病毒蛋白相互作用。在这种情况下，一些天然产物在纳摩尔浓度下具有抗病毒活性（例如石蒜碱、高三尖杉酯碱、橄榄苦苷、哇巴因、紫堇碱和 7-甲氧基隐石松定），可以作为进一步药物开发的先导化合物，或者作为药物设计的模板。此外，有相当数量的具有抗冠状病毒活性的天然产物是一些常见膳食补充剂的主要成分，可以利用这些成分来提高普通人群在某些流行病中的免疫力。
