Hall Kelly A, Singh Mandeep, Mukherjee Sutapa, Palmer Lyle J
School of Public Health, University of Adelaide, North Terrace, Adelaide, South Australia.
Department of Anesthesia, Toronto Western Hospital, University Health Network, Toronto, Canada.
J Clin Sleep Med. 2020 Jul 15;16(7):1179-1187. doi: 10.5664/jcsm.8456.
Obstructive sleep apnea (OSA) is a common condition with significant symptoms and long-term adverse cognitive, mental health, vascular, and respiratory sequelae. Physical activity has been recognized as a key determinant for good health and has been associated with lower risk of these sequelae. We hypothesized that increased physical activity may be associated with a decreased prevalence of OSA.
This cross-sectional study used baseline questionnaire data from the Ontario Health Study, a population-based cohort of residents of Ontario, Canada. Participants were adults who provided lifestyle, medical, socio-demographic, and sleep health information. The study sample consisted of 155,448 men (39.8%) and women (60.2%). The prevalence of physician-diagnosed OSA in this cohort was 6.9%. Logistic regression models were used to investigate the association of OSA with physical activity. Missing data were imputed using a multiple imputation by chained equation approach.
In multivariable analyses adjusted for potential confounding factors, increased total physical activity (metabolic equivalent [h/wk]) (odds ratio [OR] = .98, 95% confidence interval [CI] = .96 to 1.00), vigorous-intensity activity (OR = .98, 95% CI = .97 to 1.00), and walking (OR = .98, 95% CI = .96 to 1.00) were all associated (all P ≤ .045) with decreased prevalence of OSA. Moderate-intensity activity was not associated with risk of OSA (P = .826).
Independent of known risk factors for OSA, including body mass index, increased levels of physical activity, including walking, were associated with a prevalence of OSA. Our results highlight the importance of physical activity as a preventive measure for sleep apnea.
阻塞性睡眠呼吸暂停（OSA）是一种常见病症，具有明显症状以及长期不良的认知、心理健康、血管和呼吸方面的后遗症。体育活动已被视为健康的关键决定因素，并且与这些后遗症的较低风险相关。我们假设增加体育活动可能与OSA患病率降低有关。
这项横断面研究使用了安大略健康研究的基线问卷数据，该研究是基于加拿大安大略省居民的队列研究。参与者为提供生活方式、医疗、社会人口统计学和睡眠健康信息的成年人。研究样本包括155448名男性（39.8%）和女性（60.2%）。该队列中医生诊断的OSA患病率为6.9%。使用逻辑回归模型研究OSA与体育活动的关联。缺失数据采用链式方程多重插补法进行插补。
在针对潜在混杂因素进行调整的多变量分析中，总体育活动量（代谢当量[小时/周]）增加（优势比[OR]=0.98，95%置信区间[CI]=0.96至1.00）、剧烈强度活动（OR=0.98，95%CI=0.97至1.00）和步行（OR=0.98，95%CI=0.96至1.00）均与OSA患病率降低相关（所有P≤0.045）。中等强度活动与OSA风险无关（P=0.826）。
独立于OSA的已知风险因素（包括体重指数），体育活动水平增加，包括步行，与OSA患病率相关。我们的结果强调了体育活动作为睡眠呼吸暂停预防措施的重要性。
