Children's Cancer Hospital, Egypt (CCHE), Cairo, Egypt.
Department of Clinical Oncology, Ain Shams University, Cairo, Egypt.
Future Oncol. 2020 May;16(15):1043-1051. doi: 10.2217/fon-2020-0066. Epub 2020 Apr 6.
Scarce data assessing the real value of whole lung irradiation (WLI) in Ewing's sarcoma (ES) with lung-only metastasis, with published conflicting results. We studied the impact of WLI in a homogenous pediatric population. Retrospective study evaluating the survival outcomes of WLI in these patients. Out of 163 metastatic ES; 41 patients were eligible for WLI. 30 patients (73.1%) received WLI (+ve) while 11 patients (26.8%) did not receive WLI (-ve). Five-year event-free survival was statistically significant in WLI (+ve). Five-year pulmonary relapse-free survival showed trend for improvement with WLI (+ve), while 5-year overall survival was not statistically significant between the two arms. WLI added significantly to the long term clinical outcome of metastatic ES patients, with no irreversible toxicity.
关于仅有肺部转移的尤文肉瘤（ES）患者中全肺照射（WLI）的实际价值的评估数据稀缺，且已有文献的结果相互矛盾。我们在同质的儿科人群中研究了 WLI 的影响。 这项回顾性研究评估了 WLI 对这些患者生存结局的影响。 在 163 例转移性 ES 中；41 例患者符合 WLI 条件。30 例患者（73.1%）接受了 WLI（阳性），而 11 例患者（26.8%）未接受 WLI（阴性）。WLI（阳性）的 5 年无事件生存率具有统计学意义。WLI（阳性）有改善 5 年肺无复发生存率的趋势，而两组之间 5 年总生存率无统计学差异。 WLI 显著改善了转移性 ES 患者的长期临床结局，且无不可逆转的毒性。
