Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Breast Dis. 2020;39(2):71-83. doi: 10.3233/BD-190422.
With an aging society, Korean women ≥70 years of age are increasingly being diagnosed with breast cancer.
To investigate the clinicopathological and biological characteristics of breast cancer in elderly Korean women and compare them with breast cancer in elderly (≥70 years) women globally and in Korean women of all ages.
We retrospectively reviewed the clinicopathological and biological features of breast cancer in elderly Korean women (≥70 years; n = 87) who sought treatment during 2004-2014 from a single institution. These data were indirectly compared with data of Korean women of all ages (nationwide Korean Breast Cancer Registry) or elderly women globally (meta-analysis).
Compared to elderly women with breast cancer globally, Korean elderly women had a more symptomatic presentation, lower ER expression, and overexpression or amplification of human epidermal growth factor receptor 2. Compared to Korean women of all ages with breast cancer, elderly Korean women presented with advanced tumor stages, larger tumor size, more lymph node involvement, and more luminal B and basal-like subtypes.
Breast cancer had a more aggressive clinicopathological and biological characteristics in elderly Korean women than in Korean women of all ages or elderly women globally.
随着社会老龄化，70 岁以上的韩国女性被诊断出患有乳腺癌的比例越来越高。
探讨老年韩国女性乳腺癌的临床病理和生物学特征，并与全球和韩国所有年龄段老年女性的乳腺癌进行比较。
我们回顾性分析了 2004 年至 2014 年期间在一家医疗机构就诊的 87 例≥70 岁老年韩国女性乳腺癌患者的临床病理和生物学特征。这些数据与韩国所有年龄段女性（全国性韩国乳腺癌登记处）或全球老年女性（荟萃分析）的数据进行间接比较。
与全球老年乳腺癌女性相比，韩国老年女性的临床表现更为明显，雌激素受体表达水平较低，人表皮生长因子受体 2 过表达或扩增。与韩国所有年龄段的乳腺癌女性相比，老年韩国女性的肿瘤分期较晚，肿瘤体积较大，淋巴结受累较多，腔型 B 和基底样亚型较多。
与韩国所有年龄段的女性或全球老年女性相比，老年韩国女性乳腺癌具有更具侵袭性的临床病理和生物学特征。
