Facultad de Medicina Torreon, Universidad Autónoma de Coahuila, Torreon, Mexico.
Instituto de Ciencia y Medicina Genómica, Torreon, Mexico.
Genet Test Mol Biomarkers. 2020 Jun;24(6):375-380. doi: 10.1089/gtmb.2019.0266. Epub 2020 Apr 6.
To analyze the association of polymorphisms in the (rs3740199 and rs1871054) and (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. A total of 296 individuals were included in the study. Primary KOA was confirmed according to the criteria established by the American College of Rheumatology. A real-time PCR-based DNA genotyping method was used to evaluate the rs3740199, rs1871054, and rs2073508 polymorphisms in 132 cases and 164 controls. Our results demonstrate that the rs3740199 polymorphism was significantly associated with primary KOA under the recessive model ( = 0.036). However, after performing a multinomial logistic regression model, no significant association was found ( = 0.722). Furthermore, no associations for the rs1871054 and rs2073508 polymorphisms were observed in this study. These findings suggest that polymorphisms within the and genes may not have a significant influence on primary KOA susceptibility in the Mexican Mestizo population; however, inclusion of other ethnic groups and a larger sample size are needed to more fully analyze the role of these polymorphisms with KOA risk.
分析 （rs3740199 和 rs1871054）和 （rs2073508）基因多态性与墨西哥北部人群膝骨关节炎（KOA）的关联。本研究共纳入 296 例患者。根据美国风湿病学会制定的标准，确诊为原发性 KOA。采用基于实时 PCR 的 DNA 基因分型方法，对 132 例病例和 164 例对照的 rs3740199、rs1871054 和 rs2073508 多态性进行评估。我们的结果表明，在隐性模型下，rs3740199 多态性与原发性 KOA 显著相关（ = 0.036）。然而，在进行多项逻辑回归模型后，未发现显著相关性（ = 0.722）。此外，本研究未观察到 rs1871054 和 rs2073508 多态性与 KOA 的相关性。这些发现表明， 基因和 基因内的多态性可能对墨西哥梅斯蒂索人群原发性 KOA 的易感性没有显著影响；然而，需要包括其他种族群体和更大的样本量，以更全面地分析这些多态性与 KOA 风险的关系。
