Department of Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil.
Medical School of Jundiaí, Brazil.
Respir Med. 2020 May;166:105950. doi: 10.1016/j.rmed.2020.105950. Epub 2020 Mar 30.
To describe trends of hospital admissions due to asthma from 2008 to 2015 and to evaluate their relationship with trends of inhaled corticosteroids (ICS) provision by the government in Brazil.
We used Brazilian Government data to calculate hospital admission rates due to asthma, number of physicians, number of hospital beds, number of subjects that received ICS per 100,000 inhabitants in Brazil and in each of its municipalities for each year of the study. We performed Poisson Multilevel Regression Analyses to evaluate the relationship between the trends of hospital admission rates due to asthma with the trends of the number of subjects that had been receiving ICS during the study period. The analyses were adjusted for the number of physicians and hospital beds.
The number of patients who received ICS/100,000 inhabitants increased from 2008 to 2015 (943.9-1988.5). Hospital admissions/100,000 inhabitants decreased in patients aged 5-14 years (148.3-110.9) and in patients aged 15-39 years (59.9-32.3); the reduction was greater in municipalities in which ICS provision increased. The number of physicians/100,000 inhabitants increased and the number of hospital beds/100,000 inhabitants decreased in the study period. The increase in the number of physicians and in the number of subjects that received ICS were associated with reduction in hospital admissions.
We found that provision of ICS by the Brazilian Government was associated with a decrease of hospital admissions for asthma in the municipalities and country levels from 2008 to 2015.
描述 2008 年至 2015 年因哮喘住院的趋势，并评估其与巴西政府提供吸入性皮质类固醇（ICS）的趋势之间的关系。
我们使用巴西政府的数据来计算哮喘住院率、医生人数、医院床位数、每年每 10 万居民接受 ICS 的人数以及巴西和每个直辖市的人数。我们进行泊松多层回归分析，以评估哮喘住院率的趋势与研究期间接受 ICS 治疗的人数趋势之间的关系。分析调整了医生人数和医院床位数。
接受 ICS/10 万居民的人数从 2008 年到 2015 年增加（943.9-1988.5）。5-14 岁患者（148.3-110.9）和 15-39 岁患者（59.9-32.3）的住院人数/10 万居民减少；ICS 供应增加的直辖市减少幅度更大。研究期间，每 10 万居民的医生人数增加，每 10 万居民的医院床位数减少。医生人数和接受 ICS 的人数增加与住院人数减少有关。
我们发现，巴西政府提供 ICS 与 2008 年至 2015 年哮喘住院人数在直辖市和全国水平的下降有关。
