Williams P E, Catanese T, Lucey E G, Goldspink G
Muscle Research Unit, University of Hull, England.
J Anat. 1988 Jun;158:109-14.
The loss of serial sarcomeres which results when muscles are immobilised in a shortened position is accompanied by an increase in the proportion of collagen and an increased muscle stiffness. In order to determine whether it is lack of stretch or lack of contractile activity which is the main factor involved in these changes experiments were carried out using different combinations of immobilisation and electrical stimulation. It was found that the connective tissue accumulation that occurs in inactive muscles can be prevented either by passive stretch or by active stimulation. It was also shown that in muscle that is working over a reduced range there is, as in muscle immobilised in the shortened position, a reduction in serial sarcomeres. In this case, however, there is no concomitant increase in connective tissue, again indicating that contractile activity is important for the maintenance of normal muscle compliance.
当肌肉固定在缩短位置时，连续肌节的丧失伴随着胶原蛋白比例的增加和肌肉僵硬度的增加。为了确定是缺乏拉伸还是缺乏收缩活动是这些变化的主要因素，使用固定和电刺激的不同组合进行了实验。结果发现，通过被动拉伸或主动刺激都可以防止不活动肌肉中发生的结缔组织积累。还表明，在活动范围减小的肌肉中，如同固定在缩短位置的肌肉一样，连续肌节会减少。然而，在这种情况下，结缔组织并没有随之增加，这再次表明收缩活动对于维持正常的肌肉顺应性很重要。
