Peck D D, Thompson F N, Jernigan A, Kiser T E
University of Georgia, Athens 30602.
J Anim Sci. 1988 Nov;66(11):2930-6. doi: 10.2527/jas1988.66112930x.
Morphine (M), an opioid agonist, was administered to postpartum (PP) Angus cows to investigate opioid modulation of gonadotropin secretion. In Exp. 1, eight PP cows (36.9 +/- 2.3 d) received either M (1 mg/kg; n = 4) or saline solution (S) (n = 4) via i.v. injection 36 h after calf removal. Morphine decreased (P less than .01) the number of serum LH pulses (3.0 +/- 1.1 pre- vs .3 +/- .3 post-pulses/h) and, compared with pretreatment values (3.3 mg/ml), decreased (P less than .05) mean LH at 105 min (2.1 ng/ml) through 270 min 1.9 ng/ml +/- .4). Serum prolactin (PRL) increased (P less than .01) following M from 16.4 ng/ml to a peak of 59.3 ng/ml (+/- 3.9). Serum FSH concentrations were unaffected. In Exp. 2, M (.31 mg/kg i.v. injection followed by .15 mg/(kg.h) infusion; n = 6) or S (n = 6) treatments were given for 7 h beginning 36 h after calf removal. Serum LH was similar between groups during the pretreatment and the first 6 h of infusion, but M decreased (P less than .001) the number of serum LH pulses (.44 +/- .09 vs .06 +/- .04 pulses/h). Morphine increased (P less than .05) serum PRL. It is concluded that M differentially modulated gonadotropin secretion in the cow such that PRL increased, LH decreased and FSH was unchanged.
阿片类激动剂吗啡（M）被用于产后（PP）的安格斯母牛，以研究阿片类物质对促性腺激素分泌的调节作用。在实验1中，八头产后母牛（36.9±2.3天）在犊牛出生后36小时通过静脉注射接受吗啡（1毫克/千克；n = 4）或生理盐水（S）（n = 4）。吗啡减少了（P＜0.01）血清促黄体生成素（LH）脉冲的数量（脉冲前3.0±1.1次/小时与脉冲后0.3±0.3次/小时），并且与预处理值（3.3毫克/毫升）相比，在105分钟（2.1纳克/毫升）至270分钟（1.9纳克/毫升±0.4）期间平均LH降低（P＜0.05）。血清催乳素（PRL）在注射吗啡后从16.4纳克/毫升增加到峰值59.3纳克/毫升（±3.9）（P＜0.01）。血清促卵泡生成素（FSH）浓度未受影响。在实验2中，犊牛出生后36小时开始，吗啡（静脉注射0.31毫克/千克，随后以0.15毫克/（千克·小时）输注；n = 6）或生理盐水（n = 6）处理7小时。在预处理期间和输注的前6小时，两组之间的血清LH相似，但吗啡减少了（P＜0.001）血清LH脉冲的数量（0.44±0.09次/小时与0.06±0.04次/小时）。吗啡增加了（P＜0.05）血清PRL。得出的结论是，吗啡对母牛促性腺激素的分泌有不同的调节作用，使得PRL增加，LH减少，FSH不变。
