Department of Respiratory and Critical Care Medicine, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei Province, China.
Department of Thoracic Surgery, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei Province, China.
Cell Transplant. 2020 Jan-Dec;29:963689720914245. doi: 10.1177/0963689720914245.
The association between the polymorphism of transforming growth factor (TGF)-β1 and risk of radiation pneumonitis has been extensively investigated; however, conclusive results were unavailable. Eligible studies were identified from the database of Medline, Web of Science, EMBASE, and CNKI (China Knowledge Resource Integrated Database) up to September 2019. The odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of the relationship. The results showed that there were associations between TGF 869 T/C (rs1982073) and risks of radiation pneumonitis. Subgroup analyses showed that TGF 869 T/C was associated with risk of radiation pneumonitis in Caucasians (OR [95% CI]: 0.45 [0.31 to 0.67] for C carriers vs. TT). In addition, subgroup analyses also suggested that the C allele was associated with decreased risks of radiation pneumonitis among hospital-based case-control studies (0.56 [0.39 to 0.82] for C carriers vs. TT). Meanwhile, C allele was also suggested to be associated with decreased risk of radiation pneumonitis among PCC (0.60 [0.38 to 0.96] for C carriers vs. TT). Especially, C allele was also found to be associated with decreased risk of radiation pneumonitis from the participants with lung cancer (0.57 [0.37 to 0.90] for C carriers vs. TT). Our meta-analysis shows that T allele in TGF 869 T/C is significantly associated with the increased risk of radiation pneumonitis, especially for Caucasians, and for the participants with lung cancer.
转化生长因子（TGF）-β1 多态性与放射性肺炎风险的相关性已被广泛研究；然而，尚无定论。从 Medline、Web of Science、EMBASE 和中国知网（CNKI）数据库中检索到截至 2019 年 9 月的合格研究。使用比值比（OR）和 95%置信区间（95%CI）来评估相关性的强度。结果表明，TGF869T/C（rs1982073）与放射性肺炎的风险存在关联。亚组分析显示，TGF869T/C 与白种人放射性肺炎的风险相关（C 携带者与 TT 的 OR[95%CI]：0.45[0.31 至 0.67]）。此外，亚组分析还表明，C 等位基因与基于医院的病例对照研究中放射性肺炎风险降低相关（C 携带者与 TT 的 OR[95%CI]：0.56[0.39 至 0.82]）。同时，C 等位基因也与 PCC 中放射性肺炎风险降低相关（C 携带者与 TT 的 OR[95%CI]：0.60[0.38 至 0.96]）。特别是，在肺癌患者中，C 等位基因也与放射性肺炎风险降低相关（C 携带者与 TT 的 OR[95%CI]：0.57[0.37 至 0.90]）。我们的荟萃分析表明，TGF869T/C 中的 T 等位基因与放射性肺炎风险增加显著相关，尤其是在白种人和肺癌患者中。
