转化生长因子-β1 869C/T基因多态性与放射性肺炎的关系
Effect of transforming growth factor-β1 869C/T polymorphism and radiation pneumonitis.
作者信息
Wang Yingtian, Wang Xingguang, Wang Xiyan, Zhang Deyong, Jiang Shujuan
机构信息
Department of Respiratory Medicine, Dongying People's Hospital of Shandong Province Dongying 257091, Shandong, China.
Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong, China.
出版信息
Int J Clin Exp Pathol. 2015 Mar 1;8(3):2835-9. eCollection 2015.
Abstract
BACKGROUND
The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted.
METHODS
Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models.
RESULTS
There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR=1.77; 95% CI, 1.27-2.47; P=0.0007).
CONCLUSION
This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.
摘要
背景
转化生长因子-β1（TGFβ1）869C/T多态性与放射性肺炎（RP）易感性相关。然而，结果仍存在争议。因此，进行了一项荟萃分析。
方法
通过使用NCBI、Medline、科学网和Embase数据库系统检索相关研究。采用随机效应模型估计汇总比值比（OR）和相应的95%置信区间（CI）。
结果
TGFβ1 869C/T多态性与RP易感性之间存在显著关联（OR=1.77；95%CI，1.27-2.47；P=0.0007）。
结论
本研究表明，TGFβ1 869C/T多态性是RP的一个危险因素。
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