Syngenta Crop Protection AG, Chemical Research, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland.
Bioorg Med Chem. 2020 May 15;28(10):115471. doi: 10.1016/j.bmc.2020.115471. Epub 2020 Mar 31.
An overview is given of the significance of multicomponent reactions in the synthesis of agrochemicals. The most important applications of multicomponent condensations, such as the Biginelli reaction, Bucherer-Bergs reaction, Hantzsch dihydropyridine synthesis, Kabachnik-Fields reaction, Mannich reaction, Passerini reaction, Petasis reaction, Strecker reaction, Ugi reaction and Willgerodt-Kindler reaction, to the synthesis of herbicidally, fungicidally and insecticidally active compounds are presented. Also the mode of action and biological activity of these multicomponent reaction products are reported.
概述了多组分反应在农用化学品合成中的重要性。介绍了多组分缩合反应(如Biginelli 反应、Bucherer-Bergs 反应、Hantzsch 二氢吡啶合成、Kabachnik-Fields 反应、Mannich 反应、Passerini 反应、Petasis 反应、Strecker 反应、Ugi 反应和Willgerodt-Kindler 反应)在合成具有除草、杀菌和杀虫活性的化合物方面的最重要应用。还报告了这些多组分反应产物的作用方式和生物活性。