优化 PSMA 放射性配体疗法的机制见解。
Mechanistic Insights for Optimizing PSMA Radioligand Therapy.
机构信息
Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
出版信息
Clin Cancer Res. 2020 Jun 15;26(12):2774-2776. doi: 10.1158/1078-0432.CCR-20-0209. Epub 2020 Apr 6.
PSMA radioligand therapy is a promising new class of therapy for prostate cancer. Heterogeneity of PSMA expression is an important factor explaining variability in clinical results. The ability to visualize the target with theranostics provides unique mechanistic insights. Potential clinically applicable strategies to improve patient selection and optimize therapeutic efficacy are discussed..
PSMA 放射性配体疗法是前列腺癌治疗的一个很有前景的新领域。PSMA 表达的异质性是解释临床结果差异的一个重要因素。用治疗诊断学来可视化目标提供了独特的机制见解。讨论了潜在的可用于临床的改善患者选择和优化治疗效果的策略。
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