Lauterbach Lukas, Dickschat Jeroen S
Kekulé-Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
Org Biomol Chem. 2020 Jun 24;18(24):4547-4550. doi: 10.1039/d0ob00606h.
A sesquiterpene synthase from Streptomyces bungoensis was characterised and produces the new compound bungoene. The enzyme mechanism was deeply investigated using isotopically labelled substrates. Two other enzymes from S. bungoensis made epi-isozizaene and pentalenene. Synthetic oxidative chemistry towards structurally related fusagramineol and pentalenal was explored.
对来自邦戈链霉菌的一种倍半萜合酶进行了表征，该酶可产生新化合物邦戈烯。使用同位素标记的底物对该酶的作用机制进行了深入研究。邦戈链霉菌的另外两种酶可生成表异紫穗槐烯和戊塔烯。探索了针对结构相关的夫萨格拉米醇和戊塔烯醛的合成氧化化学。
