抗抑郁药在焦虑青年 3 至 12 年随访中的应用：CAMELS 试验结果。
Antidepressant Use in a 3- to 12-Year Follow-up of Anxious Youth: Results from the CAMELS Trial.
机构信息
Department of Behavioral Psychology, Kennedy Krieger Institute/Johns Hopkins School of Medicine, 720 Aliceanna Street, Baltimore, MD, 210202, USA.
Department of Psychology, Temple University, Philadelphia, PA, USA.
出版信息
Child Psychiatry Hum Dev. 2021 Feb;52(1):41-48. doi: 10.1007/s10578-020-00983-w.
The current study explored whether patient characteristics predicted patterns of antidepressant use (i.e., never used, single episode of use, or two or more episodes) in a naturalistic follow-up. Participants in the child/adolescent multimodal (CAMS) extended long-term study. (n = 318) indicated medication use over the course of eight follow-up visits, 3-12 years after receiving treatment in CAMS. 40.6% of participants reported never using an antidepressant during follow-up, 41.4% reported a single episode of antidepressant use, and 18.0% reported multiple episodes of antidepressant use. Greater baseline anxiety severity marginally predicted a single episode of antidepressant use; baseline depression severity predicted multiple episodes of use. Reasons for discontinuing antidepressants included perceived ineffectiveness (31.8%), side effects (25.5%), and improvement in symptoms (18.5%). Exploratory analyses examined predictors of medication use. Findings suggest that antidepressant use is common among anxious youth, as is discontinuation of antidepressant use. Clinical implications and future directions are discussed.
本研究旨在探讨在自然随访中，患者特征是否可以预测抗抑郁药的使用模式（即从未使用、单次使用或两次或更多次使用）。研究参与者为儿童/青少年多模式（CAMS）扩展长期研究中的（n=318）。他们在 CAMS 治疗后 3-12 年内，在 8 次随访就诊中报告了用药情况。40.6%的参与者报告在随访期间从未使用过抗抑郁药，41.4%报告单次使用过抗抑郁药，18.0%报告多次使用过抗抑郁药。基线时更严重的焦虑程度略微预测单次使用抗抑郁药；基线抑郁严重程度预测多次使用。停止使用抗抑郁药的原因包括认为无效（31.8%）、副作用（25.5%）和症状改善（18.5%）。探索性分析检查了药物使用的预测因素。研究结果表明，抗抑郁药在焦虑青年中很常见，抗抑郁药的停药也很常见。讨论了临床意义和未来方向。
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