Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
Faculty of Medicine, Department of Hematology, Hacettepe University, Ankara, Turkey.
Support Care Cancer. 2020 Dec;28(12):5851-5860. doi: 10.1007/s00520-020-05432-x. Epub 2020 Apr 6.
The aim of this study was to determine effectiveness of an individual exercise program by starting before hematopoietic stem cell transplantation (HSCT) and continued with home exercise program after discharge up to 100 days after transplantation.
Totally, 50 patients were included in this study, and participants were assigned to two groups as intervention group (IG, n = 25) and control group (CG, n = 25). Participants were assessed at three time points: before HSCT, at the discharge, and at the 100th day after HSCT. Functional exercise capacity, physical functions, muscle strength, cognitive functions, quality of life, fatigue, and emotional status of the individuals were assessed. For IG, aerobic, muscle strengthening, endurance, and stretching exercises were performed through hospitalization, and an individual exercise and walking program was advised as home exercise program after discharge.
Peripheral muscle strength and quality of life level was higher in IG than CG as a result of inpatient supervised exercise program (p ˂ 0.05). At the 100th day, positive effects of the home exercise program on cardiopulmonary exercise capacity, peripheral muscle strength, quality of life, and fatigue level continued when compared with CG (p ˂ 0.05).
As a result of our study, an exercise program continued up to 100 days after HSCT which is individual and partly supervised by a physiotherapist has positive effects on physical functions, clinical status, fatigue, and quality of life level throughout HSCT. Exercise programs for individuals undergoing HSCT should be performed day by day according to the patients' daily clinical and hematologic status and their performance capacity.
本研究旨在确定在造血干细胞移植（HSCT）前开始进行个体化运动方案的效果，并在出院后继续进行家庭运动方案，直至移植后 100 天。
本研究共纳入 50 例患者，将患者分为干预组（IG，n=25）和对照组（CG，n=25）。在三个时间点评估参与者：HSCT 前、出院时和 HSCT 后 100 天。评估个体的功能运动能力、身体功能、肌肉力量、认知功能、生活质量、疲劳和情绪状态。对于 IG，在住院期间进行有氧运动、肌肉强化、耐力和伸展运动，出院后建议进行个体化运动和步行方案作为家庭运动方案。
由于住院期间的监督运动方案，IG 的外周肌肉力量和生活质量水平高于 CG（p<0.05）。在第 100 天，与 CG 相比，家庭运动方案对心肺运动能力、外周肌肉力量、生活质量和疲劳水平的积极影响仍在继续（p<0.05）。
本研究结果表明，在 HSCT 后持续 100 天的个体化运动方案，部分由物理治疗师监督，对整个 HSCT 期间的身体功能、临床状况、疲劳和生活质量水平都有积极影响。正在接受 HSCT 的个体的运动方案应根据患者的日常临床和血液学状况及其运动能力每天进行。
