Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Department of Radiology; Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Med Glas (Zenica). 2020 Aug 1;17(2):445-450. doi: 10.17392/1108-20.
Aim Schizophrenia is a mental disorder and one of the suspected causes is cytokines. One of them is tumour necrosis factor-alpha (TNF-α). Cytokines have the potential to affect cognitive function. The study aimed to find a correlation of TNF-α level with the Mini-Mental State Examination (MMSE) score in patients with schizophrenia (PwS), and comparing the level of TNF-α levels between PwS and healthy controls. Methods We conducted a cross-sectional analytic study and the study designs were correlation and comparative analysis, i.e. using a Mann-Whitney U test. A total number of 100 subjects were collected, and they were divided into two groups of PwS and control group, respectively. Results The results found that most of the PwS subjects were 39 men (78.0%), while the control group were 28 men (56.%). The differences in TNF-α levels between PwS and control groups were found to be significant p<0.001, there was no significant correlation between TNF-α level and the score of MMSE of the PwS with p = 0.938, with a very weak correlation that was r = -0.011, and a negative correlation direction. Conclusion There was a significant difference between TNF-α level of PwS and control group, i.e. PwS group had lower TNF-α level compared to the control group. The TNF-α level of PwS group had a very weak effect on the cause of cognitive dysfunction in PwS group, yet the higher level of it could reduce MMSE score in PwS group.
目的 精神分裂症是一种精神障碍，其中一个疑似病因是细胞因子。其中一种是肿瘤坏死因子-α（TNF-α）。细胞因子有可能影响认知功能。本研究旨在探讨精神分裂症患者（PwS）的 TNF-α 水平与简易精神状态检查（MMSE）评分之间的相关性，并比较 PwS 与健康对照组之间的 TNF-α 水平。
方法 我们进行了一项横断面分析研究，研究设计为相关性和比较性分析，即使用 Mann-Whitney U 检验。共收集了 100 名受试者，他们被分为 PwS 组和对照组两组。
结果 结果发现，大多数 PwS 患者为男性（78.0%），共 39 人，而对照组为男性（56.0%），共 28 人。PwS 组与对照组之间的 TNF-α 水平差异有统计学意义（p<0.001），TNF-α 水平与 PwS 的 MMSE 评分之间无显著相关性（p = 0.938），相关性非常弱（r = -0.011），呈负相关方向。
结论 PwS 组的 TNF-α 水平与对照组有显著差异，即 PwS 组的 TNF-α 水平低于对照组。PwS 组的 TNF-α 水平对 PwS 组认知功能障碍的病因影响较弱，但 TNF-α 水平较高可能会降低 PwS 组的 MMSE 评分。
