Department of Psychiatry Faculty of Medicine Universitas Sumatera Utara.
Centre of Preclinical and Clinical Medicine Research National Research and Innovation Agency.
Med Arch. 2023;77(5):363-369. doi: 10.5455/medarh.2023.77.363-369.
Schizophrenia is a complex disorder involving multiple genes with mild to moderate effects and non-genetic risk factors such as environmental and psychological influences that alter brain chemistry. Significant reduction in interleukin-2 production by peripheral lymphocytes is an immunological finding replicated in schizophrenia across various countries. Investigations on the interleukin-2 -330 T/G polymorphism in people with schizophrenia (PWS) are still minimal, and the study location involves only a few countries with different results. Therefore, this study aims to examine the effect of interleukin-2 -330 T/G polymorphisms in people with schizophrenia among the Batak and Javanese ethnic groups in Indonesia, particularly in North Sumatra.
This study used purposive non-probability sampling to recruit people with schizophrenia with 120 Batak and 120 Javanese subjects who were hospitalized at Prof. M. Ildrem Mental Hospital, Medan, Indonesia. The interleukin-2 -330 T/G polymorphism was examined by the PCR method.
The results showed that the genotype frequency of the Batak people with schizophrenia is as follows: GG 11.7%, TG 53.3% and TT 35%. Furthermore, the group of Javanese people with schizophrenia is as follows: GG 23.3%, TG 44.2% and TT 32.5%. The OR for the genotypic comparison of GG was found to be 2.154 with 95% CI 0.992-4.678, p=0.053, while that of the TG genotype was 0.892 with 95% CI 0.505-1.574 and p=0.693. The T allele was higher than the G allele in Batak and Javanese ethnic groups, as demonstrated by p=0.713, OR=0.919 with 95% CI 0.641-1.318.
There is no statistically significant difference between the occurrence frequency of alleles. In addition, there is no significant relationship between the GG and the TG genotype of the interleukin-2 - 330T/G polymorphism in people with schizophrenia among the Batak and the Javanese ethnic groups.
精神分裂症是一种复杂的疾病，涉及多个具有轻度到中度影响的基因，以及非遗传风险因素，如改变大脑化学物质的环境和心理影响。外周淋巴细胞白细胞介素-2 产生的显著减少是在不同国家的精神分裂症中复制的免疫学发现。对精神分裂症患者白细胞介素-2-330T/G 多态性的研究仍然很少，而且研究地点只涉及几个结果不同的国家。因此，本研究旨在检查白细胞介素-2-330T/G 多态性在印度尼西亚巴塔克和爪哇族精神分裂症患者中的作用，特别是在北苏门答腊。
本研究采用目的非概率抽样方法招募了 120 名巴塔克人和 120 名爪哇精神分裂症住院患者，他们均在印度尼西亚棉兰的 M. Ildrem 精神医院住院。通过 PCR 法检测白细胞介素-2-330T/G 多态性。
结果表明，巴塔克精神分裂症患者的基因型频率如下：GG 11.7%，TG 53.3%和 TT 35%。此外，爪哇精神分裂症患者的基因型频率如下：GG 23.3%，TG 44.2%和 TT 32.5%。GG 基因型的比较的 OR 为 2.154，95%CI 为 0.992-4.678，p=0.053，而 TG 基因型的 OR 为 0.892，95%CI 为 0.505-1.574，p=0.693。巴塔克和爪哇族群体中 T 等位基因高于 G 等位基因，p=0.713，OR=0.919，95%CI 为 0.641-1.318。
等位基因的发生频率无统计学差异。此外，巴塔克和爪哇族精神分裂症患者白细胞介素-2-330T/G 多态性的 GG 和 TG 基因型之间没有显著关系。
