白细胞介素-2-330T/G 多态性对巴塔克族和爪哇族精神分裂症患者的影响。

The Effect of Interleukin-2 -330 T/G Polymorphism in People with Schizophrenia Among The Batak and Javanese Ethnic Groups.

机构信息

Department of Psychiatry Faculty of Medicine Universitas Sumatera Utara.

Centre of Preclinical and Clinical Medicine Research National Research and Innovation Agency.

出版信息

Med Arch. 2023;77(5):363-369. doi: 10.5455/medarh.2023.77.363-369.

DOI:10.5455/medarh.2023.77.363-369

PMID:38299092

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10825752/

Abstract

BACKGROUND

Schizophrenia is a complex disorder involving multiple genes with mild to moderate effects and non-genetic risk factors such as environmental and psychological influences that alter brain chemistry. Significant reduction in interleukin-2 production by peripheral lymphocytes is an immunological finding replicated in schizophrenia across various countries. Investigations on the interleukin-2 -330 T/G polymorphism in people with schizophrenia (PWS) are still minimal, and the study location involves only a few countries with different results. Therefore, this study aims to examine the effect of interleukin-2 -330 T/G polymorphisms in people with schizophrenia among the Batak and Javanese ethnic groups in Indonesia, particularly in North Sumatra.

METHOD

This study used purposive non-probability sampling to recruit people with schizophrenia with 120 Batak and 120 Javanese subjects who were hospitalized at Prof. M. Ildrem Mental Hospital, Medan, Indonesia. The interleukin-2 -330 T/G polymorphism was examined by the PCR method.

RESULT

The results showed that the genotype frequency of the Batak people with schizophrenia is as follows: GG 11.7%, TG 53.3% and TT 35%. Furthermore, the group of Javanese people with schizophrenia is as follows: GG 23.3%, TG 44.2% and TT 32.5%. The OR for the genotypic comparison of GG was found to be 2.154 with 95% CI 0.992-4.678, p=0.053, while that of the TG genotype was 0.892 with 95% CI 0.505-1.574 and p=0.693. The T allele was higher than the G allele in Batak and Javanese ethnic groups, as demonstrated by p=0.713, OR=0.919 with 95% CI 0.641-1.318.

CONCLUSION

There is no statistically significant difference between the occurrence frequency of alleles. In addition, there is no significant relationship between the GG and the TG genotype of the interleukin-2 - 330T/G polymorphism in people with schizophrenia among the Batak and the Javanese ethnic groups.

摘要

背景

精神分裂症是一种复杂的疾病，涉及多个具有轻度到中度影响的基因，以及非遗传风险因素，如改变大脑化学物质的环境和心理影响。外周淋巴细胞白细胞介素-2 产生的显著减少是在不同国家的精神分裂症中复制的免疫学发现。对精神分裂症患者白细胞介素-2-330T/G 多态性的研究仍然很少，而且研究地点只涉及几个结果不同的国家。因此，本研究旨在检查白细胞介素-2-330T/G 多态性在印度尼西亚巴塔克和爪哇族精神分裂症患者中的作用，特别是在北苏门答腊。

方法

本研究采用目的非概率抽样方法招募了 120 名巴塔克人和 120 名爪哇精神分裂症住院患者，他们均在印度尼西亚棉兰的 M. Ildrem 精神医院住院。通过 PCR 法检测白细胞介素-2-330T/G 多态性。

结果

结果表明，巴塔克精神分裂症患者的基因型频率如下：GG 11.7%，TG 53.3%和 TT 35%。此外，爪哇精神分裂症患者的基因型频率如下：GG 23.3%，TG 44.2%和 TT 32.5%。GG 基因型的比较的 OR 为 2.154，95%CI 为 0.992-4.678，p=0.053，而 TG 基因型的 OR 为 0.892，95%CI 为 0.505-1.574，p=0.693。巴塔克和爪哇族群体中 T 等位基因高于 G 等位基因，p=0.713，OR=0.919，95%CI 为 0.641-1.318。