Hassani Hanieh, Chen Jung-Wei, Zhang Wu, Hamra William
Private Practitioner Advanced Education Program in Pediatric Dentistry, Loma Linda University, Loma Linda, CA, USA.
Advanced Education Program in Pediatric Dentistry, Department of Pediatric Dentistry, Loma Linda University, Loma Linda, CA, USA.
Cleft Palate Craniofac J. 2020 Jun;57(6):762-769. doi: 10.1177/1055665620908150. Epub 2020 Apr 7.
The aim of the current study is as follows: (1) to study whether wearing the presurgical nasoalveolar molding appliance (PNAM) had facilitated the establishment of and () and to determine other factors including pH and caries susceptibility associated with wearing the PNAM.
Saliva samples of 61 infants (4.5 ± 2.06 months old) were collected from the following 3 groups: PNAM (n = 23), healthy (n = 30), and cleft lip and palate (CLP) without any treatment (n = 8). Saliva samples were assessed using selective agar to enumerate total and and subjected to adenosine triphosphate (ATP)-driven bioluminescence determinations using a luciferin-based assay system, and pH level was evaluated. One-way analysis of variance with least significant difference post hoc test ( < .05) and Pearson correlation were used to evaluate , , pH, and ATP levels.
A total of 63 patients (30 healthy patients, 23 patients with cleft lip/palate who had PNAM appliance and 8 patients with cleft lip/palate who did not use the appliance) were seen in this study. There is a significant difference in pH ( = .012), Caries Risk Test ( < .001), colony count ( < .001), Caries Risk Test ( < .001), and colony count ( < .001) among the 3 groups (PNAM > CLP > healthy). The ATP level was not significantly different among the 3 groups.
Higher bacterial count and lower pH were found in the PNAM group. Cleft lip and/or palate patients wearing the PNAM appliance are at higher risk for dental caries.
本研究的目的如下：（1）研究佩戴术前鼻牙槽塑形矫治器（PNAM）是否有助于建立[具体内容缺失]以及确定与佩戴PNAM相关的其他因素，包括pH值和龋齿易感性。
从以下3组中收集了61名婴儿（4.5±2.06个月大）的唾液样本：PNAM组（n = 23）、健康组（n = 30）和未接受任何治疗的唇腭裂（CLP）组（n = 8）。使用选择性琼脂评估唾液样本以计数总[具体内容缺失]和[具体内容缺失]，并使用基于荧光素的检测系统进行三磷酸腺苷（ATP）驱动的生物发光测定，并评估pH值水平。使用最小显著差异事后检验的单因素方差分析（P <.05）和Pearson相关性来评估[具体内容缺失]、[具体内容缺失]、pH值和ATP水平。
本研究共纳入63例患者（30例健康患者、23例佩戴PNAM矫治器的唇腭裂患者和8例未使用该矫治器的唇腭裂患者）。3组之间在pH值（P =.012）、龋齿风险测试（P <.001）、[具体内容缺失]菌落计数（P <.001）、龋齿风险测试（P <.001）和[具体内容缺失]菌落计数（P <.001）方面存在显著差异（PNAM组>CLP组>健康组）。3组之间的ATP水平无显著差异。
PNAM组中发现细菌计数较高且pH值较低。佩戴PNAM矫治器的唇裂和/或腭裂患者患龋齿的风险较高。
